Search results for FRS2

Showing 28 results out of 234

×

Species

Types

Compartments

Reaction types

Search properties

Species

Types

Compartments

Reaction types

Search properties

Protein (6 results from a total of 9)

Identifier: R-HSA-190244
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: FRS2: Q8WU20
Identifier: R-HSA-170963
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: FRS2: Q8WU20
Identifier: R-HSA-162551
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: FRS2: Q8WU20
Identifier: R-HSA-170959
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: FRS2: Q8WU20
Identifier: R-HSA-190355
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: FRS2: Q8WU20
Identifier: R-HSA-1270462
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: FRS2: Q8WU20

Complex (6 results from a total of 78)

Identifier: R-NUL-9700008
Species: Rattus norvegicus, Homo sapiens
Compartment: plasma membrane
Identifier: R-HSA-9700002
Species: Homo sapiens
Compartment: plasma membrane
Identifier: R-HSA-5654196
Species: Homo sapiens
Compartment: plasma membrane
Identifier: R-HSA-5654201
Species: Homo sapiens
Compartment: plasma membrane
Identifier: R-HSA-5654200
Species: Homo sapiens
Compartment: plasma membrane
Identifier: R-HSA-5654193
Species: Homo sapiens
Compartment: plasma membrane

Reaction (6 results from a total of 124)

Identifier: R-NUL-9031971
Species: Rattus norvegicus, Mus musculus, Homo sapiens
Compartment: plasma membrane, cytosol
Recombinant rat Ntrk2 (TrkB), activated by recombinant human BDNF or NTF4, phosphorylates mouse Frs2 on unknown tyrosine residues (Yuen and Mobley 1999).
Identifier: R-HSA-9028728
Species: Homo sapiens
Compartment: plasma membrane, cytosol
Activated NTRK2 (TRKB) phosphorylates FRS2 (also known as FRS2alpha or SNT) on unknown tyrosine residues (Yuen and Mobley 1999, Easton et al. 1999).
Identifier: R-NUL-9700145
Species: Rattus norvegicus, Homo sapiens
Compartment: cytosol, plasma membrane
Rat Frs2 co-immunoprecipitates with human ALK when co-expressed in HEK203 cells. Interaction is dependent on the tyrosine kinase activity of ALK, although a precise binding site for FRS2 has not been identified (Degoutin et al, 2007).
Identifier: R-HSA-9700164
Species: Homo sapiens
Compartment: plasma membrane
FRS2 is phosphorylated downstream of ALK in a manner that depends on ALK kinase activity (Degoutin et al, 2007).
Identifier: R-HSA-5654679
Species: Homo sapiens
Compartment: cytosol, extracellular region, plasma membrane
Grb2 bound to tyrosine phosphorylated FRS2 forms a ternary complex with Cbl through the binding of the SH3 domains of Grb2 to a proline rich region in Cbl. Grb2-mediated recruitment of Cbl results in ubiquitination of FGFR and FRS2. Cbl is a multidomain protein that posses an intrinsic ubiquitin ligase activity and also functions as a platform for recruitment of a variety of signaling proteins. Multiple mechanisms appear to be required for downregulation of FGFR, as internalization of the receptor is reduced but not abolished if recruitment of CBL to FRS2 is compromised by mutation of GRB2-binding sites.
Identifier: R-HSA-5654672
Species: Homo sapiens
Compartment: cytosol, extracellular region, plasma membrane
Grb2 bound to tyrosine phosphorylated FRS2 forms a ternary complex with Cbl through the binding of the SH3 domains of Grb2 to a proline rich region in Cbl. Grb2-mediated recruitment of Cbl results in ubiquitination of FGFR and FRS2. Cbl is a multidomain protein that posses an intrinsic ubiquitin ligase activity and also functions as a platform for recruitment of a variety of signaling proteins. Multiple mechanisms appear to be required for downregulation of FGFR, as internalization of the receptor is reduced but not abolished if recruitment of CBL to FRS2 is compromised by mutation of GRB2-binding sites.

Pathway (6 results from a total of 19)

Identifier: R-HSA-9028731
Species: Homo sapiens
Adapter proteins FRS2 and FRS3 can both bind to the cytoplasmic tail of activated NTRK2 (TRKB) receptor, which is followed by NTRK2-mediated phosphorylation of FRS2 and FRS3. NTRK2 signaling through FRS3 has been poorly characterized (Easton et al. 1999, Yuen and Mobley 1999, Dixon et al. 2006, Zeng et al. 2014). Phosphorylated FRS2 is known to recruit GRB2 (presumably in complex with SOS1) and PTPN11 (SHP2) to activated NTRK2, leading to augmentation of RAS signaling (Easton et al. 1999, Easton 2006).
Identifier: R-HSA-170968
Species: Homo sapiens
The adaptor protein Frs2 (Fibroblast growth factor receptor substrate 2) can mediate the prolonged activation of the MAPK (ERK) cascade.
Identifier: R-HSA-5654706
Species: Homo sapiens
The FRS family of scaffolding adaptor proteins has two members, FRS2 (also known as FRS2 alpha) and FRS3 (also known as FRS2beta or SNT-2). Activation of FGFR tyrosine kinase allows FRS proteins to become phosphorylated on tyrosine residues and then bind to the adaptor GRB2 and the tyrosine phosphatase PPTN11/SHP2. Subsequently, PPTN11 activates the RAS-MAP kinase pathway and GRB2 activates the RAS-MAP kinase , PI-3-kinase and ubiquitinations/degradation pathways by binding to SOS, GAB1 and CBL, respectively, via the SH3 domains of GRB2. FRS2 acts as a central mediator in FGF signaling mainly because it induces sustained levels of activation of ERK with ubiquitous expression.


Identifier: R-HSA-5654693
Species: Homo sapiens
The FRS family of scaffolding adaptor proteins has two members, FRS2 (also known as FRS2 alpha) and FRS3 (also known as FRS2beta or SNT-2). Activation of FGFR tyrosine kinase allows FRS proteins to become phosphorylated on tyrosine residues and then bind to the adaptor GRB2 and the tyrosine phosphatase PPTN11/SHP2. Subsequently, PPTN11 activates the RAS-MAP kinase pathway and GRB2 activates the RAS-MAP kinase , PI-3-kinase and ubiquitinations/degradation pathways by binding to SOS, GAB1 and CBL, respectively, via the SH3 domains of GRB2. FRS2 acts as a central mediator in FGF signaling mainly because it induces sustained levels of activation of ERK with ubiquitous expression.


Identifier: R-HSA-5654700
Species: Homo sapiens
The FRS family of scaffolding adaptor proteins has two members, FRS2 (also known as FRS2 alpha) and FRS3 (also known as FRS2beta or SNT-2). Activation of FGFR tyrosine kinase allows FRS proteins to become phosphorylated on tyrosine residues and then bind to the adaptor GRB2 and the tyrosine phosphatase PPTN11/SHP2. Subsequently, PPTN11 activates the RAS-MAP kinase pathway and GRB2 activates the RAS-MAP kinase , PI-3-kinase and ubiquitinations/degradation pathways by binding to SOS, GAB1 and CBL, respectively, via the SH3 domains of GRB2. FRS2 acts as a central mediator in FGF signaling mainly because it induces sustained levels of activation of ERK with ubiquitous expression.


Identifier: R-HSA-5654712
Species: Homo sapiens
The FRS family of scaffolding adaptor proteins has two members, FRS2 (also known as FRS2 alpha) and FRS3 (also known as FRS2beta or SNT-2). Activation of FGFR tyrosine kinase allows FRS proteins to become phosphorylated on tyrosine residues and then bind to the adaptor GRB2 and the tyrosine phosphatase PPTN11/SHP2. Subsequently, PPTN11 activates the RAS-MAP kinase pathway and GRB2 activates the RAS-MAP kinase , PI-3-kinase and ubiquitinations/degradation pathways by binding to SOS, GAB1 and CBL, respectively, via the SH3 domains of GRB2. FRS2 acts as a central mediator in FGF signaling mainly because it induces sustained levels of activation of ERK with ubiquitous expression.


Set (4 results from a total of 4)

Identifier: R-HSA-191477
Species: Homo sapiens
Compartment: plasma membrane
Identifier: R-HSA-191476
Species: Homo sapiens
Compartment: plasma membrane
Identifier: R-HSA-2029940
Species: Homo sapiens
Compartment: plasma membrane
Identifier: R-HSA-2029963
Species: Homo sapiens
Compartment: plasma membrane
Cite Us!