Search results for FTO

Showing 4 results out of 4

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Species

Types

Compartments

Search properties

Protein (1 results from a total of 1)

FTO

Identifier: R-HSA-8857715
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: UniProt: FTO: Q9C0B1

Interactor (1 results from a total of 1)

Identifier: Q9C0B1-2
Species: Homo sapiens
Primary external reference: UniProt: Q9C0B1-2

Complex (1 results from a total of 1)

Identifier: R-HSA-8857714
Species: Homo sapiens
Compartment: nucleoplasm

Reaction (1 results from a total of 1)

Identifier: R-HSA-8857692
Species: Homo sapiens
Compartment: nucleoplasm
Fe2+- and oxoglutarate-dependent ALKB oxygenase family members are able to oxidatively demethylate alkylated DNA and RNA, thereby repairing them. The family members alpha-ketoglutarate-dependent dioxygenase FTO (FTO) and RNA demethylase ALKBH5 (ALKBH5) localise to the nucleus and can both specifically demethylate N(6)-methyladenosine (m6A) RNA, the most abundant internal modification of messenger RNA (mRNA) in higher eukaryotes (Han et al. 2010, Jia et al. 2011, Xu et al. 2014). FTO contributes to the regulation of the global metabolic rate, energy expenditure and energy homeostasis and is associated with body mass index (BMI) (Dina et al. 2007, Frayling et al. 2007, Zhang et al. 2015; reviews - Zhao et al. 2014, Merkestein & Sellayah 2015). ALKBH5 could play a role in spermatogenesis. Alkbh5-deficient male mice have increased N6-methyladenosine in mRNA and are characterised by impaired fertility (Zheng et al. 2013).
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