Search results for GAL3ST1

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Species

Types

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Reaction types

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Protein (1 results from a total of 1)

Identifier: R-HSA-1631586
Species: Homo sapiens
Compartment: Golgi membrane
Primary external reference: UniProt: GAL3ST1: Q99999

Reaction (1 results from a total of 1)

Identifier: R-HSA-9844587
Species: Homo sapiens
Compartment: Golgi membrane
Galactosylceramide sulfotransferase (GAL3ST1, CST) catalyzes the transfer of sulfate from phosphoadenylylsulfate (PAPS) onto position 3 of beta-galactosyl residues in glycerolipids and sphingolipids yielding sulfogalactoceramide (sulfatide) or sulfo-LacCer (SM3), and adenosine-3',5'-bisphosphate (Honke et al., 1996, 1997). Sulfatides are abundant but not essential in the myelin sheath. GAL3ST1 deficiency leads to the arrest of spermatogenesis. It ameliorates L-selectin-dependent monocyte infiltration in renal interstitial inflammation, indicating that sulfatide is an endogenous ligand of L-selectin (reviewed by Honke, 2013).
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