Search results for GAPDHS

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Protein (3 results from a total of 3)

Identifier: R-HSA-372873
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: GAPDHS: O14556
Identifier: R-HSA-6813805
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: GAPDHS: O14556
Identifier: R-HSA-70428
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: GAPDH: P04406
While there are multiple human glyceraldehyde 3-phosphate dehydrogenase-like pseudogenes, there is only one glyceraldehyde 3-phosphate dehydrogenase gene expressed in somatic tissue (Benham and Povey 1989). Consistent with this conclusion, the homogeneous enzymes purified from various human tissues had indistinguishable physical and immunochemical properties (Heinz and Freimuller 1982), and studies of human erythrocytes of various ages suggested that variant forms of the enzyme arise as a result of post-translational modifications (Edwards et al. 1976). There is, however, an authentic second isoform of glyceraldehyde 3-phosphate dehydrogenase whose expression is confined to spermatogenic cells of the testis (Welch et al. 2000).

Set (1 results from a total of 1)

Identifier: R-HSA-372871
Species: Homo sapiens
Compartment: cytosol

Reaction (1 results from a total of 1)

Identifier: R-HSA-70482
Species: Homo sapiens
Compartment: cytosol
The reversible reduction of 1,3BPG (1,3-bisphosphoglycerate) to form G3P (glyceraldehyde-3-phosphate) is catalyzed by cytosolic GAPDH (glyceraldehyde-3-phosphate dehydrogenase) tetramer.

There are multiple human GAPDH-like pseudogenes, but only one GAPDH gene expressed in somatic tissue (Benham and Povey 1989). Consistent with this conclusion, the homogeneous enzymes purified from various human tissues had indistinguishable physical and immunochemical properties (Heinz and Freimuller 1982), and studies of human erythrocytes of various ages suggested that variant forms of the enzyme arise as a result of post-translational modifications (Edwards et al. 1976). There is, however, an authentic second isoform of GAPDH whose expression is confined to spermatogenic cells of the testis (Welch et al. 2000).

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