Search results for GBA

Showing 8 results out of 8

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Species

Types

Compartments

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Protein (4 results from a total of 4)

Identifier: R-HSA-6813790
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: GBA1: P04062
Identifier: R-HSA-1605775
Species: Homo sapiens
Compartment: lysosomal membrane
Primary external reference: UniProt: GBA1: P04062
Identifier: R-HSA-1861791
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: GBA2: Q9HCG7
Identifier: R-HSA-1861749
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: GBA3: Q9H227

Complex (1 results from a total of 1)

Identifier: R-HSA-1605675
Species: Homo sapiens
Compartment: lysosomal membrane

Reaction (3 results from a total of 3)

Identifier: R-HSA-1861789
Species: Homo sapiens
Compartment: cytosol
Human glucosylceramidase 3 (GBA3) hydrolyses the glucosidic bond of glucocerebrosides to form ceramide in the cytosol. GBA3 may be involved in the intestinal absorption and metabolism of dietary flavonoid glycosides (Berrin et al. 2002, Nemeth et al. 2003). However, the activity of GBA3 is relatively low and its significance in vivo is not clear (Dekker et al., 2011).
Identifier: R-HSA-1605591
Species: Homo sapiens
Compartment: lysosomal membrane, lysosomal lumen
Human lysosomal glucosylceramidase (GBA1) hydrolyzes the glucosidic bond of glucocerebrosides (GlcCer) to form ceramide (Dinur et al. 1986). GBA1 requires a low-weight, non-enzymatic protein (one of the sphingolipids activator proteins) called Saposin-C (SAP-C) which acts with GBA1 to form an activated complex (Salvioli et al. 2000; Abdul-Hammed et al., 2017). Defects in GBA1 are the cause of Gaucher disease (GD) (MIM:230800), the most common glycolipid storage disorder, characterized by storage of glucocerebroside in the liver, spleen, and marrow (Beutler & Gelbart 1996).
Identifier: R-HSA-1861788
Species: Homo sapiens
Compartment: plasma membrane, cytosol
Human glucosylceramidase 2 (GBA2) hydrolyzes the glucosidic bond of glucocerebrosides (GlcCer) to form ceramide at the plasma membrane (Matern et al. 2001, Boot et al. 2007).
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