Search results for GEM

Showing 16 results out of 33

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Protein (3 results from a total of 13)

GEM

Identifier: R-HSA-9769962
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: GEM: P55040
Identifier: R-HSA-8932878
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: GEMIN8: Q9NWZ8
Identifier: R-HSA-8932892
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: UniProt: GEMIN8: Q9NWZ8

DNA Sequence (1 results from a total of 1)

Identifier: R-HSA-9769961
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: ENSEMBL: ENSEMBL:ENSG00000164949

Reaction (3 results from a total of 10)

Identifier: R-HSA-9769011
Species: Homo sapiens
Compartment: nucleoplasm
Based on a study in rat primary neurons, NPAS4 and its heterodimerization partners ARNT and ARNT2 bind to the GEM gene locus and NPAS4 significantly upregulates GEM gene transcription (Brigidi et al. 2019). In a mouse model system, Gem gene was also identified as an Npas4 target gene which is induced by Npas4 and promotes neuroprotection after ischemic brain injury (Takahashi et al. 2021).
Identifier: R-HSA-9769014
Species: Homo sapiens
Compartment: nucleoplasm, plasma membrane
Based on a study in rat primary neurons, NPAS4 significantly upregulates GEM gene transcription (Brigidi et al. 2019). In a mouse model system, Gem gene was also identified as an Npas4 target gene which is induced by Npas4 and promotes neuroprotection after ischemic brain injury (Takahashi et al. 2021). GEM is also induced in human cerebral organoids cultured under ischemic conditions (Takahashi et al. 2021).
Identifier: R-HSA-68712
Species: Homo sapiens
Compartment: cytosol
From the end of anaphase and throughout G1, the Cdh1 (FZR1) containing anaphase-promoting complex (APC/C:Cdh1) ubiquitinates geminin (GMNN), targeting it for degradation and enabling release of CDT1 and the subsequent association of CDT1 with the replication origins.The presence of an APC destruction box in geminin and its APC/C-mediated ubiquitination and degradation was first demonstrated in Xenopus egg extracts (McGarry and Kirschner 1998) and was later confirmed in human cells, where it was shown to largely depend on Cdh1 and not Cdc20 component of the APC/C (Pfleger et al. 2001; Di Fiore and Pines 2007; Machida and Dutta 2007). Emi1 (FBXO5) mediated inhibition of the APC/C:Cdh1 complex in S and G2 phases is needed for stabilization of geminin and prevention of re-replication (Di Fiore and Pines 2007; Machida and Dutta 2007).

Complex (1 results from a total of 1)

Identifier: R-HSA-9769968
Species: Homo sapiens
Compartment: nucleoplasm

Interactor (1 results from a total of 1)

Identifier: A6NCL1
Species: Homo sapiens
Primary external reference: UniProt: A6NCL1

Drug (2 results from a total of 2)

Identifier: R-ALL-9734460
Compartment: nucleoplasm
Primary external reference: Guide to Pharmacology: gemfibrozil: 3439
Identifier: R-ALL-9709171
Compartment: extracellular region
Primary external reference: PubChem Compound: Gemigliptin: 11953153

Person (1 results from a total of 1)

Authored Pathways: 0
Reviewed Pathways: 1
Authored Reactions: 0
Reviewed Reactions: 1

Pathway (1 results from a total of 1)

Identifier: R-HSA-9768919
Species: Homo sapiens
Compartment: nucleoplasm
NPAS4 is a basic helix loop helix (bHLH) transcription factor that needs to dimerize with another bHLH protein, either ARNT, ARNT2 or ARNTL, in order to be able to bind to target DNA (Ooe et al. 2004; Ooe et al. 2009; Brigidi et al. 2019).

NPAS4 is implicated as a transcriptional regulator of genes involved in neuronal development such as CDK5 (Yun et al. 2013), CDK5R1 (Yun et al. 2013), RBFOX3 (NeuN) (Yun et al. 2013), BDNF (Pruunsild et al. 2011) and RET (Sribudiani et al. 2011), genes involved in synaptogenesis and synaptic transmission such as NPTX2 (Lin et al. 2008), MDM2 (Yoshihara et al. 2014; Lv et al. 2021), FOS (Ramamoorthi et al. 2011), IQSEC3 (Kim et al. 2021), PLK2 (Weng et al. 2018) and possibly other genes (Lin et al. 2008; Shan et al. 2018), circadian rhythm-related genes such as NAMPT (West et al. 2013), and genes involved in neuroprotection upon injury such as GEM (Takahashi et al. 2021), SYT10 (Woitecki et al. 2016) and possibly other genes (Qiu et al. 2013). In pancreatic beta-cell, NPAS4 is implicated as a regulator of insulin synthesis under stress conditions (Sabatini et al. 2013).

The circadian clock regulated gene CRY1 was identified as NPAS4 target gene in sheep brain (West et al. 2013), but this finding was not reproduced in the high throughput identification of NPAS4 targets in rat primary neurons (Brigidi et al. 2019). The DBNL gene, encoding Drebrin, a dendrytic cytoskeleton modulator, was initially identified as a gene directly upregulated by Npas4 (Ooe et al. 2004), but a high throughput study of NPAS4 targets showed DBNL gene expression to be repressed by NPAS4, although not significantly (Brigidi et al. 2019).

NPAS4 is expressed in endothelial cells and may play a role in angiogenesis (Esser et al. 2017).

Set (2 results from a total of 2)

Identifier: R-HSA-419057
Species: Homo sapiens
Compartment: cytosol
ROCK I (alternatively called ROK ?) and ROCK II (also known as Rho kinase or ROK ?) were originally isolated as RhoA-GTP interacting proteins. The kinase domains of ROCK I and ROCK II are 92% identical, and so far there is no evidence that they phosphorylate different substrates. RhoA, RhoB, and RhoC associate with and activate ROCK but other GTP-binding proteins can be inhibitors, e.g. RhoE, Rad and Gem. PDK1 kinase promotes ROCK I activity not through phosphorylation but by blocking RhoE association. PLK1 can phosphorylate ROCK II and this enhances the effect of RhoA. Arachidonic acid can activate ROCK independently of Rho.
Identifier: R-HSA-4687776
Species: Homo sapiens
Compartment: cytosol
ROCK I (alternatively called ROK ?) and ROCK II (also known as Rho kinase or ROK ?) were originally isolated as RhoA-GTP interacting proteins. The kinase domains of ROCK I and ROCK II are 92% identical, and so far there is no evidence that they phosphorylate different substrates. RhoA, RhoB, and RhoC associate with and activate ROCK but other GTP-binding proteins can be inhibitors, e.g. RhoE, Rad and Gem. PDK1 kinase promotes ROCK I activity not through phosphorylation but by blocking RhoE association. PLK1 can phosphorylate ROCK II and this enhances the effect of RhoA. Arachidonic acid can activate ROCK independently of Rho.

Icon (1 results from a total of 1)

Gem

Species: Homo sapiens
Curator: Kaiqiang You
Designer: Cristoffer Sevilla
Gem icon
Nuclear bodies frequently found near or associated with Cajal bodies (also called coiled bodies or CBs). Gemini of coiled bodies, or 'gems', are similar in size and shape to CBs, and often indistinguishable under the microscope. Unlike CBs, gems do not contain small nuclear ribonucleoproteins (snRNPs); they contain a protein called survivor of motor neurons (SMN) whose function relates to snRNP biogenesis. Gems are believed to assist CBs in snRNP biogenesis, and to play a role in the etiology of spinal muscular atrophy (SMA)
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