Search results for GGPS1

Showing 9 results out of 9

×

Species

Types

Compartments

Reaction types

Search properties

Species

Types

Compartments

Reaction types

Search properties

Protein (1 results from a total of 1)

Identifier: R-HSA-191415
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: GGPS1: O95749

DNA Sequence (1 results from a total of 1)

Identifier: R-HSA-2393998
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: ENSEMBL: ENSEMBL:ENSG00000152904

Reaction (4 results from a total of 4)

Identifier: R-HSA-2426161
Species: Homo sapiens
Compartment: nucleoplasm
SREBP1A (SREBF1A) or SREBP2, together with NF-Y and SP1, bind and transactivate the promoter of the GGPS1 gene (Reed et al. 2008).
Identifier: R-HSA-9717830
Species: Homo sapiens
Compartment: cytosol
Further condensation of an isopentenyl pyrophosphate (IPPP) with geranyl pyrophosphate (GPP) to form farnesyl pyrophosphate (FAPP) is catalyzed by the prenyltransferases FPP synthase and GGPP synthase (Kavanagh et al, 2006).
Identifier: R-HSA-9717834
Species: Homo sapiens
Compartment: cytosol
The family of enzymes called prenyltransferases is involved in the biosynthesis of isoprenoids. Two members of this family are known to catalyse the sequential condensation of isopentenyl pyrophosphate (IPPP) to DMAPP: farnesyl pyrophosphate synthase dimer (FPPS dimer) and geranylgeranyl pyrophosphate synthetase hexamer (GGPPS hexamer) (Kavanaugh et al, 2006). Both enzymes utlise Mg2+ as cofactor (Chang et al. 2021).
Identifier: R-HSA-1655832
Species: Homo sapiens
Compartment: nucleoplasm, cytosol
The GGPS1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
SREBF1A (SREBP1A) and SREBF2 (SREBP2) bind the promoter of the Geranylgeranyl pyrophosphate synthase gene (GGPS1) and enhance transcription (Sakakura et al. 2001, Reed et al. 2008, reviewed in Horton et al. 2002)

Complex (3 results from a total of 3)

Identifier: R-HSA-981557
Species: Homo sapiens
Compartment: cytosol
Identifier: R-HSA-981569
Species: Homo sapiens
Compartment: cytosol
Identifier: R-HSA-2426126
Species: Homo sapiens
Compartment: nucleoplasm
Cite Us!