Search results for GGT5

Showing 4 results out of 4

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Species

Types

Compartments

Search properties

Protein (2 results from a total of 2)

Identifier: R-HSA-265312
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: GGT5: P36269
Identifier: R-HSA-265313
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: P36269

Complex (1 results from a total of 1)

Identifier: R-HSA-265314
Species: Homo sapiens
Compartment: plasma membrane

Reaction (1 results from a total of 1)

Identifier: R-HSA-266046
Species: Homo sapiens
Compartment: plasma membrane, extracellular region
The reversible conversion of leukotriene C4 (LTC4) to leukotriene D4 (LTD4) is catalysed by gamma-glutamyl transferases 1 (GGT1) and 5 (GGT5). GGTs are present on the outer surface of plasma membranes and are a heterodimer of a heavy and a light chain. Its action involves the hydrolysis of the gamma-glutamyl peptide bond of glutathione and glutathione conjugates, releasing glutamate. In this example, LTC4 is a glutathione conjugate that is hydrolysed to LTD4 (Anderson et al. 1982, Wickham et al. 2011).
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