Search results for GLDC

Showing 4 results out of 4

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Species

Types

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Species

Types

Compartments

Reaction types

Search properties

Protein (1 results from a total of 1)

Identifier: R-HSA-5693966
Species: Homo sapiens
Compartment: mitochondrial matrix
Primary external reference: UniProt: GLDC: P23378

Complex (1 results from a total of 1)

Identifier: R-HSA-5693954
Species: Homo sapiens
Compartment: mitochondrial matrix

Reaction (1 results from a total of 1)

Identifier: R-HSA-5693967
Species: Homo sapiens
Compartment: mitochondrial matrix
The simplest amino acid, glycine, is catabolised by several different pathways. The major pathway is via the glycine cleavage system. In the first reaction, glycine (Gly) is decarboxylated to carbon dioxide (CO2) and aminomethyl group (NH2CH2) by mitochondrial glycine dehydrogenase (decarboxylating) (GLDC, P protein), a dimeric protein using pyridoxal 5-phosphate (PXPL) as cofactor per subunit (Kume et al. 1991). Mitochondrial glycine cleavage system H protein (GCSH) is used as a co-substrate in this reaction. GCSH uses lipoate as a cofactor which accepts the aminomethylgroup from glycine decarboxylation to form a S-aminomethyldihydrolipoylated protein (GCSH:SAMDLL) (Fujiwara et al. 1991, Fujiwara et al. 1991).

Pathway (1 results from a total of 1)

Identifier: R-HSA-6783984
Species: Homo sapiens
The simplest amino acid, glycine, is catabolised by several different pathways. The major pathway is via the glycine cleavage system, comprising dimeric P protein (GLDC), T protein (AMT, GCST), dimeric L protein (DLD) and H protein (GCSH) (Kikuchi et al. 2008).
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