Search results for GLYCTK

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Species

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Reaction types

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Protein (1 results from a total of 1)

Identifier: R-HSA-6799244
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: GLYCTK: Q8IVS8

Reaction (1 results from a total of 1)

Identifier: R-HSA-6799495
Species: Homo sapiens
Compartment: cytosol
D-glyceric acid (DGA) is an intermediate of serine catabolism and of a minor pathway of fructose metabolism. The only known fate of DGA is phosphorylation to 3-phospho-D-glyceric acid (3PDGA) by cytosolic glycerate kinase (GLYCTK) (Yu et al. 2006). Defects in GLYCTK can cause D-glyceric aciduria (D-GA; MIM:220120), a rare inborn error of serine and fructose metabolism where DGA is excreted in large amounts in the urine. A variable phenotype is observed, ranging from severe mental retardation and death to milder speech delays and normal development (Van Schaftingen 1989, Sass et al. 2010).
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