Search results for GNAS

Showing 8 results out of 8

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Species

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Interactor (1 results from a total of 1)

GNAS

Identifier: P63092-2
Species: Homo sapiens
Primary external reference: UniProt: P63092-2

Set (1 results from a total of 1)

GNAS

Identifier: R-HSA-8873941
Species: Homo sapiens
Compartment: plasma membrane

Protein (2 results from a total of 2)

GNAS1

Identifier: R-HSA-8873940
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: GNAS: Q5JWF2

GNAS2

Identifier: R-HSA-164387
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: GNAS: P63092

Reaction (3 results from a total of 3)

G alpha (s):GTP:SRC dissociates

Identifier: R-HSA-8964287
Species: Homo sapiens
Compartment: cytosol, plasma membrane
Upon autophosphorylation, SRC dissociates from GNAS and is subsequently activated. GNAS increases SRC enzymatic activity by decreasing Km and not affecting Vm. Physiologically, the SRC family have implications in cell growth and cancer.

G alpha (s):GTP:SRC catalyzes SRC to p-Y416-SRC

Identifier: R-HSA-8964252
Species: Homo sapiens
Compartment: plasma membrane
G-Protein Coupled Receptors sense extracellular signals and activate different Guanine nucleotide binding proteins. Upon activation, the alpha subunit of the G protein (GNAS) can directly bind to SRC. In the presence of active GNAS, SRC can autophosphorylate the 416-tyrosine residue, which leads to the subsequent activation of SRC. Physiologically, the SRC family have implications in cell growth and cancer. GNAS increases SRC enzymatic activity by decreasing Km and not affecting Vm.

G protein alpha (s):GTP binds SRC

Identifier: R-HSA-8964278
Species: Homo sapiens
Compartment: cytosol, plasma membrane
G-Protein Coupled Receptors (GPCR) sense extracellular signals and activate different Guanine nucleotide binding proteins. Upon activation, the Guanine nucleotide-binding protein G(s) subunit alpha (GNAS) can bind directly to proto-oncogene tyrosine-protein kinase Src (SRC) in vitro and in vivo. This binding results in autophosphorylation of SRC and subsequently its activation. Physiologically, the SRC family have implications in cell growth and cancer.

Icon (1 results from a total of 1)

GNAS

Species: Homo sapiens
Curator: Bruce May
Designer: Cristoffer Sevilla
GNAS icon
Generic representation of GNAS. The GNAS gene provides instructions for making one component, the stimulatory alpha subunit, of a protein complex called a guanine nucleotide-binding protein (G protein). Each G protein is composed of three proteins called the alpha, beta, and gamma subunits
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