Search results for GNB2

Showing 12 results out of 12

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Protein (5 results from a total of 5)

Identifier: R-HSA-6814421
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: GNB2: P62879
Identifier: R-HSA-164335
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: P62879
Identifier: R-HSA-8850536
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: GNB2: P62879
Identifier: R-HSA-6814202
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: P62879
Identifier: R-HSA-5626956
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: RACK1: P63244

Reaction (4 results from a total of 4)

Identifier: R-HSA-5626962
Species: Homo sapiens
Compartment: cytosol
Guanine nucleotide-binding protein subunit beta-2-like 1(GNB2L1) also known as receptor of activated protein kinase C 1 (RACK1) is reported to associate with the IKK complex in a TNF-triggered manner (Yao F et al. 2014). This interaction interfered with TRAF2-mediated recruitment and the subsequent phosphorylation of IKK triggered by TNF. By modulating the interaction between TRAF2 and the IKK complex, GNB2L1 (RACK1) regulated the level of NFkB activation in response to TNF (Yao F et al. 2014).
Identifier: R-HSA-5626982
Species: Homo sapiens
Compartment: cytosol, plasma membrane
Guanine nucleotide-binding protein subunit beta-2-like 1 (GNB2L1), which is also known as a receptor for activated protein kinase C (RACK1), interacts with NSMAF (FAN) in vitro as shown by glutathione S-transferase-based coprecipitation assays as well as coimmunoprecipitation experiments using human embryonic kidney 293 (HEK293) cells (Tcherkasowa AE et al. 2002). Confocal laser-scanning microscopy studies suggest that overexpressed NSMAF (FAN) and GNB2L1 (RACK) colocalize at the plasma membrane together with TNFR1 (Tcherkasowa AE et al. 2002). Furthemore, isolation of TNF receptors containing vesicles from TNF-stimulated Jurkat or HeLa cells by help of biotinylated TNF and MACS Streptavidin Microbeadsderived and coupled with immunoblotting assay showed that GNB2L1(RACK1) interacts with TNFR1 (Philipp S et al. 2010). The data suggest that GNB2L1(RACK1) modulates activation of neutral sphingomyelinase (N-SMASE) triggered by TNF.
Identifier: R-HSA-8850527
Species: Homo sapiens
Compartment: cytosol
PDCL (PhLP1) enables completion of folding of G-protein beta subunits 1-4 (GNB1, GNB2, GNB3 and GNB4) by the TRiC/CCT chaperonin, resulting in the release of dimers of PDCL and folded G-protein beta 1-4 (Lukov et al. 2005, Lukov et al. 2006, Howlett et al. 2009, Plimpton et al. 2015).
Identifier: R-HSA-6814119
Species: Homo sapiens
Compartment: cytosol
The TRiC/CCT chaperonin complex binds nascent, unfolded, G-protein beta subunit (GNB1, GNB2, GNB3, GNB4 or GNB5) (Wells et al. 2006). G-beta reaches a near-native state in the folding cavity of TRiC, except that TRiC cannot mediate the folding of the seven-bladed beta propeller of the G-protein beta to a stable conformation (Plimpton et al. 2015).

Set (2 results from a total of 2)

Identifier: R-HSA-8850531
Species: Homo sapiens
Compartment: cytosol
Identifier: R-HSA-8850548
Species: Homo sapiens
Compartment: cytosol

Pathway (1 results from a total of 1)

Identifier: R-HSA-6814122
Species: Homo sapiens
The chaperonin complex TRiC/CCT is needed for the proper folding of all five G-protein beta subunits (Wells et al. 2006). TRiC/CCT cooperates with the phosducin-like protein PDCL (commonly known as PhLP or PhLP1), which interacts with both TRiC/CCT and G-protein beta subunits 1-5 (GNB1, GNB2, GNB3, GNB4, GNB5) (Dupre et al. 2007, Howlett et al. 2009). PDCL enables completion of G-protein beta folding by TRiC/CCT, promotes release of folded G-protein beta subunits 1-4 (GNB1, GNB2, GNB3, GNB4) from the chaperonin complex, and facilitates the formation of the heterodimeric G-protein beta:gamma complex between G-protein beta subunits 1-4 and G-protein gamma subunits 1-12 (Lukov et al. 2005, Lukov et al. 2006, Howlett et al. 2009, Lai et al. 2013, Plimpton et al. 2015, Xie et al. 2015). In the case of G-protein beta 5 (GNB5), PDCL stabilizes the interaction of GNB5 with the TRiC/CCT and promotes GNB5 folding, thus positively affecting formation of GNB5 dimers with RGS family proteins (Howlett et al. 2009, Lai et al. 2013, Tracy et al. 2015). However, over-expression of PDCL interferes with formation of GNB5:RGS dimers as PDCL and RGS proteins bind to the same regions of the GNB5 protein (Howlett et al. 2009).
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