Search results for GNPAT

Showing 7 results out of 7

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Species

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Compartments

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Protein (3 results from a total of 3)

Identifier: R-HSA-53413
Species: Homo sapiens
Compartment: peroxisomal matrix
Primary external reference: UniProt: GNPAT: O15228
Identifier: R-HSA-1500605
Species: Homo sapiens
Compartment: peroxisomal membrane
Primary external reference: UniProt: GNPAT: O15228
Identifier: R-HSA-9033129
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: GNPAT: O15228

Reaction (3 results from a total of 3)

Identifier: R-HSA-1483002
Species: Homo sapiens
Compartment: cytosol, peroxisomal membrane
Dihydroxyacetone phosphate (DHAP) is converted to 1-acyl glycerone 3-phosphate (GO3P) by the enzyme dihydroxyacetone phosphate acyltransferase (GNPAT) (de Vet et al. 1999, Ofman et al. 1994). This reaction step links Glycerolipid metabolism to Ether lipid metabolism.
Identifier: R-HSA-75879
Species: Homo sapiens
Compartment: peroxisomal matrix
Peroxisomal glyceronephosphate O-acyltransferase (GNPAT) catalyzes the reaction of palmitoyl-CoA and DHAP to form 1-palmitoyl glycerone phosphate (1-palmitoyl dihydroxyacetone phosphate) and CoASH. The active form of the enzyme is one subunit of a heterotrimer with two molecules of the alkylglycerone phosphate synthase (AGPS) enzyme (Biermann et al. 1999). It was first purified and characterized biochemically by Ofman and Wanders (1994). Mutations in the GNPAT gene are associated with rhizomelic chondrodysplasia type 2 (Ofman et al. 1998, 2001).
Identifier: R-HSA-390427
Species: Homo sapiens
Compartment: peroxisomal matrix
Peroxisomal alkylglycerone phosphate synthase (AGPS) catalyzes the reaction of 1-palmitoylglycerone phosphate and hexadecanol to form O-hexadecylglycerone phosphate and palmitate. The active form of the enzyme is post-translationally cleaved to remove its 58 aminoterminal residues, has a molecule of FAD as a cofactor, and occurs in the peroxisome as a complex with glyceronephosphate O-acyltransferase (GNPAT) (Biermann et al. 1999; Bierman and van den Bosch 1999; de Vet et al. 2000).

Complex (1 results from a total of 1)

Identifier: R-HSA-76165
Species: Homo sapiens
Compartment: peroxisomal matrix
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