Search results for GPC5

Showing 10 results out of 29

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Protein (7 results from a total of 26)

Identifier: R-HSA-5362356
Species: Homo sapiens
Compartment: extracellular region
Primary external reference: UniProt: GPC5: P78333
Identifier: R-HSA-2054103
Species: Homo sapiens
Compartment: Golgi lumen
Primary external reference: UniProt: GPC5: P78333
Identifier: R-HSA-2090047
Species: Homo sapiens
Compartment: lysosomal lumen
Primary external reference: UniProt: GPC5: P78333
Identifier: R-HSA-2076472
Species: Homo sapiens
Compartment: Golgi lumen
Primary external reference: UniProt: GPC5: P78333
Identifier: R-HSA-5362430
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: GPC5: P78333
Identifier: R-HSA-2076696
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: GPC5: P78333
Identifier: R-HSA-2076676
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: GPC5: P78333

Reaction (1 results from a total of 1)

Identifier: R-HSA-5362427
Species: Homo sapiens
Compartment: plasma membrane
The establishment of a signaling gradient of Hh-Np is modulated in part by the interaction of the ligand with heparin sulphate proteoglycans (HSPGs) in the extracellular matrix (ECM) of the secreting cell. Interactions with HSPGs can influence Hh oligomerization and also impact the lateral and long-range spread of Hh ligand (reviewed in Gallet, 2011; Briscoe and Therond, 2013). Interactions with HSPGs can stimulate or restrict Hh signaling depending on the context and the particular proteoglycans involved (see for instance Witt et al, 2013; Li et al, 2011; Capurro et al, 2005; Capurro et al, 2012; reviewed in Gallet, 2011).

In vertebrate cells, the GPI-anchored HSPG glypican 5 (GPC5) has been shown to stimulate Hh signaling by promoting the interaction between SHH ligand and the PTCH1 receptor (Li et al, 2011; Witt et al, 2013). SHH and PTCH1 binding depends on the GAG chains of GPC5, as versions lacking the GAG insertion sites are compromised for both ligand and receptor binding, and these proteins do not stimulate Hh signaling (Li et al, 2011). Amplification of GPC5 has been observed in 20% of rhabdomyosarcomas (Williamson et al, 2007), and aberrant activation of Hh signaling in these cells promotes cellular proliferation (Li et al, 2011).

Complex (1 results from a total of 1)

Identifier: R-HSA-5362428
Species: Homo sapiens
Compartment: plasma membrane

Interactor (1 results from a total of 1)

Identifier: Q9NZD1
Species: Homo sapiens
Primary external reference: UniProt: Q9NZD1
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