Search results for GPX4

Showing 8 results out of 8

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Protein (2 results from a total of 2)

GPX4-2

Identifier: R-HSA-9020572
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: GPX4: P36969

L-selenocysteine-residue-GPX4(?-197)

Identifier: R-HSA-2142826
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: GPX4: P36969

Reaction (5 results from a total of 5)

GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE

Identifier: R-HSA-9018868
Species: Homo sapiens
Compartment: cytosol
In PMNs, cytosolic phospholipid hydroperoxide glutathione peroxidase (GPX4 isoform 2, GPX4-2) (Yagi et al. 1996) is a likely candidate for the reduction of organic hydroperoxides such as 18(S)-HpEPE to 18(S)-hydroxyeicosapentaenoic acid (18(S)-HEPE) (Han et al. 2013) using glutathione (GSH) as an electron donor (Brigelius-Flohe & Maiorino 2013).

GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE

Identifier: R-HSA-9018895
Species: Homo sapiens
Compartment: cytosol
In PMNs, cytosolic phospholipid hydroperoxide glutathione peroxidase (GPX4 isoform 2, GPX4-2) (Yagi et al. 1996) is a likely candidate for the reduction of organic hydroperoxides such as 18(R)-HpEPE to 18(R)-hydroxyeicosapentaenoic acid (18(R)-HEPE) (Han et al. 2013) using glutathione (GSH) as an electron donor (Brigelius-Flohe & Maiorino 2013).

GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA

Identifier: R-HSA-9020273
Species: Homo sapiens
Compartment: cytosol
Cytosolic phospholipid hydroperoxide glutathione peroxidase (GPX4 isoform 2, GPX4-2) (Yagi et al. 1996) is a likely candidate for the reduction of organic hydroperoxides such as 17(S)-hydroperoxy-docosahexaenoic acid (17(S)-Hp-DHA) to 17(S)-hydroxydocosahexaenoic acid (17(S)-HDHA) (Han et al. 2013) using glutathione (GSH) as an electron donor (Brigelius-Flohe & Maiorino 2013).

GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA

Identifier: R-HSA-9020271
Species: Homo sapiens
Compartment: cytosol
Cytosolic phospholipid hydroperoxide glutathione peroxidase (GPX4 isoform 2, GPX4-2) (Yagi et al. 1996) is a likely candidate for the reduction of organic hydroperoxides such as 17(R)-hydroperoxy-docosahexaenoic acid (17(R)-Hp-DHA) to 17(R)-hydroxydocosahexaenoic acid (17(R)-HDHA) (Han et al. 2013) using glutathione (GSH) as an electron donor (Brigelius-Flohe & Maiorino 2013). 17(R)-HDHA can then be transformed into 17(R)-D-resolvins and a 17-oxo electrophilic product 17-oxo-DHA (Groeger et al. 2010).

15S-HpETE is reduced to 15S-HETE by GPX1/2/4

Identifier: R-HSA-2161791
Species: Homo sapiens
Compartment: cytosol
Glutathione peroxidases (GPXs) in human platelets (either GPX1, GPX2, or GPX4 are present in the cytosol) are involved in reducing 15S-hydroperoxyeicosatetraenoic acid (15S-HpETE) to 15S-hydroxyeicosatetraenoic acid (15S-HETE) (Hill et al. 1989).

Icon (1 results from a total of 1)

GPX4

Species: Homo sapiens
Curator: Veronica Shamovsky
Designer: Cristoffer Sevilla
GPX4 icon
Phospholipid hydroperoxide glutathione peroxidase
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