Search results for GRIK2

Showing 11 results out of 11

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Protein (3 results from a total of 3)

Identifier: R-HSA-450192
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: GRIK2: Q13002
Identifier: R-HSA-451318
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: Q13002
GRIK2 is edited at the Q/R site at 621 where the glutamine is edited to arginine. GRIK2 is also edited at 571 (Y/C) where a tyrosine residue is changed to cysteine and 567 (I/V) where an isoleucine is changed to valine. All three sites are edited postranscriptionally. A fully edited GRIK2 at all three sites is totally impermeable to calcium ions.
Identifier: R-HSA-450197
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: GRIK5: Q16478

Complex (3 results from a total of 3)

Identifier: R-HSA-450890
Species: Homo sapiens
Compartment: plasma membrane
Identifier: R-HSA-451319
Species: Homo sapiens
Compartment: plasma membrane
Identifier: R-HSA-451324
Species: Homo sapiens
Compartment: plasma membrane

Interactor (1 results from a total of 1)

Identifier: Q8IY40
Species: Homo sapiens
Primary external reference: UniProt: Q8IY40

Set (1 results from a total of 1)

Identifier: R-HSA-450203
Species: Homo sapiens
Compartment: plasma membrane

Pathway (2 results from a total of 2)

Identifier: R-HSA-451307
Species: Homo sapiens
Compartment: cytosol, extracellular region, plasma membrane
Kainate receptors that are formed by subunits GRIK1 and or GRIK2 that are edited at the Q/R and other editing sites in GRIK2 are Ca2+ impermeable. They permit the passage of Na+ ions. Glutamine in GRIK1 at position 636 is replaced by arginine by an editing step which occurs posttranscriptioanlly. GRIK2 is glutamine 621 is edited to arginine. GRIK2 is also edited at 571 (Y/C) where a tyrosine residue is changed to cysteine and 567 (I/V) where an isoleucine is changed to valine. All three sites are edited postranscriptionally. A fully edited GRIK2 at all three sites is impermeable to calcium ions.
Identifier: R-HSA-451308
Species: Homo sapiens
Compartment: cytosol, extracellular region, plasma membrane
Kainate receptors that are assembled with subunits GRIK1-5, are Ca2+ permeable if GRIK1 and GRIK2 are not edited at the Q/R or other sites.
These channels permit Ca2+ upon activation by glutamate or other agonists.

Reaction (1 results from a total of 1)

Identifier: R-HSA-451311
Species: Homo sapiens
Compartment: cytosol, extracellular region, plasma membrane
Kainate receptors that are assembled with subunits GRIK1-5, are Ca2+ permeable if GRIK1 and GRIK2 are not edited at the Q/R or other sites.
These channels permit Ca2+ upon activation by glutamate or other agonists.
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