Search results for GUCY2C

Showing 7 results out of 7

×

Species

Types

Compartments

Reaction types

Search properties

Species

Types

Compartments

Reaction types

Search properties

Protein (1 results from a total of 1)

Identifier: R-HSA-8936203
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: GUCY2C: P25092

Complex (3 results from a total of 3)

Identifier: R-HSA-8936213
Species: Homo sapiens
Compartment: plasma membrane
Identifier: R-HSA-8936204
Species: Homo sapiens
Compartment: plasma membrane
Identifier: R-HSA-8936363
Species: Homo sapiens
Compartment: plasma membrane

Reaction (2 results from a total of 2)

Identifier: R-HSA-8936356
Species: Homo sapiens
Compartment: extracellular region, plasma membrane
Heat-stable enterotoxin receptor (GUCY2C, STAR) is the receptor for the endogenous peptides guanylin (GUCA2A) and uroguanylin (GUCA2B) and E.coli heat-stable enterotoxin (sta1). GUCY2C is an integral membrane protein composed of an extracellular ligand-binding domain, an intracellular domain and a guanylyl cyclase catalytic domain and functions in trimeric form (Vijayachandra et al. 2000). Once activated by its ligands, GUCY2C mediates fluid-ion homeostasis, intestinal inflammation, and cell proliferation in a cGMP-dependent manner (Arshad et al. 2013). In the intestine, E.coli heat-stable enterotoxin (sta1) binding to GUCY2C causes abnormally high levels of intracellular cGMP to be produced resulting in aberrant fluid-ion efflux, leading to secretory diarrhea, the leading cause of infectious diarrhea in humans (Basu et al. 2010, Kopic & Geibel 2010). GUCY2C requires glycosylation for correct ligand binding and cell-surface localisation. When glycosylation is prevented in systematic mutagenesis studies, both ligand binding and localisation were abolished (Arshad et al. 2013).

Na(+)/H(+) exchange regulatory cofactor NHE-RF4 (PDZD3, aka IKEPP, NHERF4) is a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable enterotoxin-mediated activation. PDZD3 is expressed in the intestinal epithelium, where it preferentially accumulates at the apical surface, and there associates with the COOH terminus of GUCY2C (Scott et al. 2002).
Identifier: R-HSA-8936214
Species: Homo sapiens
Compartment: extracellular region, plasma membrane
Heat-stable enterotoxin receptor (GUCY2C, STAR) is the receptor for the endogenous peptides guanylin (GUCA2A) and uroguanylin (GUCA2B) and E.coli heat-stable enterotoxin. GUCY2C is an integral membrane protein composed of an extracellular ligand-binding domain, an intracellular domain and a guanylyl cyclase catalytic domain and functions in trimeric form (Vijayachandra et al. 2000). Once activated by its ligands, GUCY2C mediates fluid-ion homeostasis, intestinal inflammation, and cell proliferation in a cGMP-dependent manner (Arshad et al. 2013). In the intestine, salt and fluid secretion is stimulated by E.coli heat-stable enterotoxins through activation of CUCY2C. The endogenous peptides GUCA2A and GUCA2B have structural similarity to these bacterial enterotoxins and function as mediators of Cl- and water secretion in the intestine (Hamra et al. 1993, Forte et al. 1993, Basu et al. 2010).

Icon (1 results from a total of 1)

Species: Homo sapiens
Curator: Bijay Jassal
Designer: Cristoffer Sevilla
GUCY2C icon
Heat-stable enterotoxin receptor
Cite Us!