Search results for HMGCL

Showing 8 results out of 8

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Species

Types

Compartments

Reaction types

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Protein (4 results from a total of 4)

Identifier: R-HSA-74172
Species: Homo sapiens
Compartment: mitochondrial matrix
Primary external reference: UniProt: HMGCL: P35914
Identifier: R-HSA-9033112
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: HMGCL: P35914
Identifier: R-HSA-9033125
Species: Homo sapiens
Compartment: peroxisomal matrix
Primary external reference: UniProt: HMGCL: P35914
Identifier: R-HSA-6788599
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: HMGCLL1: Q8TB92

Complex (2 results from a total of 2)

Identifier: R-HSA-74264
Species: Homo sapiens
Compartment: mitochondrial matrix
Identifier: R-HSA-6788595
Species: Homo sapiens
Compartment: cytosol

Reaction (2 results from a total of 2)

Identifier: R-HSA-6788597
Species: Homo sapiens
Compartment: cytosol
3-hydroxy-3-methylglutaryl CoA lyase (HMGCL) catalyses the cleavage of beta-hydroxy-3-methylglutaryl CoA (bHMG-CoA) to acetoacetate (ACA) and acetyl-CoA (Ac-CoA). This reaction is the common final step in ketogenesis and leucine catabolism. HMGCL isoforms are usually located to the mitochondrial matrix or peroxisomes. The mitochondrial isoform contributes to ketone body production whereas the function of the peroxisomal form is unclear. Another isoform has recently been discovered, (HMGCLL1) which is expressed mainly in liver, lung, kidney and brain and has a dual location of ER and cytosolic cellular compartments. The metabolic function of HMGCLL1 is unknown but could provide support for energy production in the tissues mentioned above (Montgomery et al. 2012, Arnedo et al. 2012).
Identifier: R-HSA-74180
Species: Homo sapiens
Compartment: mitochondrial matrix
Hydroxymethylglutaryl-CoA lyase dimer (HMGCL) in the mitochondrial matrix catalyzes the reaction of beta-hydroxy-beta-methylglutaryl coenzyme A (HMG CoA) to form acetyl-CoA and acetoacetate (Mitchell et al. 1993).
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