Search results for HMGCS1

Showing 5 results out of 5

×

Species

Types

Compartments

Reaction types

Search properties

Species

Types

Compartments

Reaction types

Search properties

Protein (1 results from a total of 1)

Identifier: R-HSA-191329
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: HMGCS1: Q01581

DNA Sequence (1 results from a total of 1)

Identifier: R-HSA-2393972
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: ENSEMBL: ENSG00000112972

Reaction (3 results from a total of 3)

Identifier: R-HSA-2426150
Species: Homo sapiens
Compartment: nucleoplasm
SREBP1A/1C/2 (SREBF1A/1C/2), together with NF-Y, bind and transactivate the promoter of the HMGCS1 gene (Maeda et al. 1998, Pai et al. 1998, Amemiya-Kudo et al. 2002, Reed et al. 2008). SREBP1A and SREBP2 activate HMGCS1 equally (Pai et al. 1998).
Identifier: R-HSA-191323
Species: Homo sapiens
Compartment: cytosol
3-hydroxy-3-methylglutaryl Coenzyme A synthase (HMG-CoA synthase) catalyzes the condensation of acetyl CoA with acetoacetyl CoA to produce HMG-CoA. There are two forms of this enzyme, cytosolic and mitochondrial. The cytosolic form is ubiquitous in the body and is involved in cholesterol biosynthesis and synthesis of other isoprenoid products. The mitochondrial form, found solely in the liver and kidney, is involved in the ketogenic pathway.
Identifier: R-HSA-1655848
Species: Homo sapiens
Compartment: nucleoplasm, cytosol
The HMGCS1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
Cite Us!