Search results for HMOX1

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Reaction (4 results from a total of 16)

Identifier: R-HSA-9708497
Species: Homo sapiens
Compartment: nucleoplasm, cytosol
The BACH1 gene produces the transcription regulator protein BACH1 which contains 736 amino acids and is 88% identical to its mouse homolog. It contains basic leucine zipper and BTB-zinc finger domains (which are directly involved in DNA binding for transcription regulation) (Blouin et al, 1999).

The let-7 microRNA (miRNA) plays important roles in human liver development and diseases such as hepatocellular carcinoma, liver fibrosis and hepatitis wherein oxidative stress accelerates the progression of these diseases. It directly acts on the 3'-UTR of BACH1 and negatively regulates expression of this protein, and thereby up-regulates heme oxygenase (HMOX1) gene expression (Hou et al, 2012).

miR-155 is one of the TNFα-inducible endothelial microRNAs that bind to the BACH1 mRNA. Increased HMOX1 expression in endothelial cells by TNFα results from miR-155-induced repression of BACH1 rather than direct induction of HMOX1 via NF-κB. miR-155 is cytoprotective during inflammation by elevating HMOX1 expression in endothelial cells (Pulkkinen et al, 2011).

The microRNA miR‐196 directly acts on the 3′‐UTR of BACH1 messenger RNA and translationally represses the expression of this protein, and up‐regulates HMOX1 (Hou et al, 2010).
Identifier: R-HSA-9707523
Species: Homo sapiens
Compartment: nucleoplasm
Heme binds to four cysteine-proline motifs in the C-terminal region of BACH1 and inhibits the DNA-binding activity of BACH1-MAFK heterodimers resulting in HMOX1 induction. MAFK separates from the complex, and heme recruits nuclear exporters for BACH1 (Yoshida et al, 1988; Ogawa et al, 2001; Suzuki et al, 2004).
Identifier: R-HSA-9708557
Species: Homo sapiens
Compartment: nucleoplasm
The leucine-rich repeat family of F-box proteins (FBXLs) function as adapter for the SKP1-CUL1-F-box protein (SCF) E3 ubiquitin ligase. FBXL17 is a regulator of the nuclear factor erythroid 2-related factor 2 (NFE2L2) oxidative stress pathway. By binding to the transcriptional repressor/regulator protein BACH1 it controls the transcription of the NFE2L2 target heme oxygenase 1 (HMOX1) via turnover of BACH1 in the absence or presence of extrinsic oxidative stress (Tan et al, 2013).
Identifier: R-HSA-9708517
Species: Homo sapiens
Compartment: nucleoplasm
The leucine-rich repeat family of F-box proteins (FBXLs) function as adapter for the SKP1-CUL1-F-box protein (SCF) E3 ubiquitin ligase. FBXL17 is a regulator of the nuclear factor erythroid 2-related factor 2 (NFE2L2) oxidative stress pathway. By binding to the transcriptional repressor/regulator protein BACH1 it controls the transcription of the NFE2L2 target heme oxygenase 1 (HMOX1) via turnover of BACH1 in the absence or presence of extrinsic oxidative stress (Tan et al, 2013).
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