Search results for HNRNPA1

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Reaction (3 results from a total of 3)

Identifier: R-HSA-9727869
Species: Homo sapiens
Compartment: cytosol
Heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1) is involved in the packaging of pre-mRNA into hnRNP particles and the transport of poly(A) mRNA from the nucleus to the cytoplasm. SARS-CoV-1 nucleocapsid protein (N), the most abundant protein in SARS infection, binds to HNRNPA1. It is unknown whether this affects host mRNA transport or viral transcription (Luo et al, 2005).
Identifier: R-HSA-6803523
Species: Homo sapiens
Compartment: nucleoplasm
Repression of FGFR2 exon IIIb splicing in mesenchymal cells depends on intronic splicing silencer (ISS) sequences upstream of exon IIIb as well as an exonic splicing element (ESE) within exon IIIb. These elements are bound by PTB1 and hnRNPA1, respectively, as part of a larger splicing complex, promoting the formation and expression of mature FGFR2c mRNA in mesenchymal cells (Carstens et al, 2000; Gil et al, 1991; Del Gatto et al, 1997; Del Gatto et al, 1999). For more detailed information on splicing and pre-mRNA maturation, please see the mRNA splicing pathway.
Identifier: R-HSA-6803838
Species: Homo sapiens
Compartment: nucleoplasm
In mesenchymal cells, FGFR2 IIIc exon splicing is favoured by the binding of PTB1 to intronic splice silencer (ISS) sequences 1 and 2 that flank the IIIb specific exon, and by the binding of hnRNPA1 to an exonic splicing silencer (ESS) within the IIIb specific exon (Del Gatto-Konczak et al, 1999; Carstens et al, 2000). Binding of these proteins to the nascent mRNA , which occurs in the context of a larger splicing complex, represses IIIb-specific alternative splicing and favours the formation of FGFR2 IIIc-specific mRNA.
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