Search results for HRASLS

Showing 5 results out of 5

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Species

Types

Compartments

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Protein (3 results from a total of 3)

Identifier: R-HSA-8858537
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: PLAAT1: Q9HDD0
Identifier: R-HSA-8858534
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: PLAAT5: Q96KN8
Identifier: R-HSA-8858536
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: PLAAT2: Q9NWW9

Set (1 results from a total of 1)

Identifier: R-HSA-8858540
Species: Homo sapiens
Compartment: cytosol

Reaction (1 results from a total of 1)

Identifier: R-HSA-8858298
Species: Homo sapiens
Compartment: cytosol, endoplasmic reticulum membrane
The H-RAS-like suppressor (HRASLS) subfamily consists of five enzymes (1–5) in humans that share sequence homology with lecithin:retinol acyltransferase (LRAT). All HRASLS members possess in vitro phospholipid metabolizing abilities including phospholipase A1/2 (PLA1/2) activities and O-acyltransferase activities for the remodeling of glycerophospholipid acyl chains (Golczak et al. 2012), as well as N-acyltransferase activities for the production of N-acylphosphatidylethanolamines (Mardian et al. 2015). Acyl chain remodelling can play a key role in regulating triglyceride accumulation and energy expenditure in adipocytes, making this process a potential target for treatment of metabolic disorders causing obesity. The example here describes the N-acyltransferase activity of HRASLSs for the production of N-acylphosphatidylethanolamines (NAPEs) (Uyama et al. 2012).
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