Search results for HRH1

Showing 4 results out of 4

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Species

Types

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Reaction types

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Species

Types

Compartments

Reaction types

Search properties

Protein (1 results from a total of 1)

Identifier: R-HSA-390908
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: HRH1: P35367

Reaction (1 results from a total of 1)

Identifier: R-HSA-390912
Species: Homo sapiens
Compartment: extracellular region, plasma membrane
The histamine H1 receptor (De Backer MD et al, 1993) is found on smooth muscle, endothelium and the CNS. Histamine released from neurons binds to the H1 receptor and causes systemic vasodilation and increased endothelial cell permeability. The effects are modulated by the activated receptor binding to the G protein alpha-q/11 subtype which can activate phospholipase C and the phosphatidylinositol (PIP2) signaling pathway (Tilly BC et al, 1990). The classical antihistamines (histamine H1 receptor antagonists) were developed in the early 1930s and were shown to reduce the effects of histamine on many tissues.

Complex (1 results from a total of 1)

Identifier: R-HSA-390885
Species: Homo sapiens
Compartment: plasma membrane

Interactor (1 results from a total of 1)

Identifier: Q14562
Species: Homo sapiens
Primary external reference: UniProt: Q14562
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