Search results for IAPP
Showing 7 results out of 7
Protein (2 results from a total of 2)
Identifier: R-HSA-186631
Species:
Homo sapiens
Compartment:
cytosol
Primary external reference: UniProt: IAPP:
P10997
Identifier: R-HSA-420076
Species:
Homo sapiens
Compartment:
extracellular region
Primary external reference: UniProt: IAPP:
P10997
DNA Sequence (1 results from a total of 1)
Identifier: R-HSA-9606123
Species:
Homo sapiens
Compartment:
nucleoplasm
Primary external reference: ENSEMBL:
ENSEMBL:ENSG00000121351
Reaction (2 results from a total of 2)
Identifier: R-HSA-211301
Species:
Homo sapiens
Compartment:
nucleoplasm,
cytosol
The IAPP gene, encoding islet amyloid precursor protein, is transcribed and its mRNA is translated. IAPP transcription is positively regulated by PDX1 transcription factor. These events and interactions are inferred from corresponding ones studied in molecular detail in the mouse.
Identifier: R-HSA-420265
Species:
Homo sapiens
Compartment:
extracellular region,
plasma membrane
Amylin (islet amyloid polypeptide, diabetes associated peptide) is a 37 amino acid peptide first purified from amyloid deposits in the pancreatic islets of type 2 diabetic patients (Nishi M et al, 1989). It is a product of the islet B-cell, along with insulin and probably has a hormonal role in the regulation of nutrient intake. Amylin receptors are multimeric complexes, formed by CT receptor (Gorn AH et al, 1992) interaction with receptor activity modifying proteins (RAMPs) (McLatchie LM et al, 1998). The CT receptor interacts with the three RAMPs, generating multiple subtypes of amylin receptor (AMY1-3).
Complex (1 results from a total of 1)
Identifier: R-HSA-420147
Species:
Homo sapiens
Compartment:
plasma membrane
Icon (1 results from a total of 1)
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