Search results for IL2

Showing 21 results out of 304

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Protein (3 results from a total of 31)

IL2

Identifier: R-HSA-447099
Species: Homo sapiens
Compartment: extracellular region
Primary external reference: UniProt: IL2: P60568
Identifier: R-HSA-449139
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: IL2RG: P31785
Identifier: R-HSA-450046
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: IL2RA: P01589

Interactor (3 results from a total of 4)

Identifier: IL2
Species: Homo sapiens
Primary external reference: UniProt: IL2
Identifier: P31785-1
Species: Homo sapiens
Primary external reference: UniProt: P31785-1
Identifier: Q9NYY1-PRO_0000015381
Species: Homo sapiens
Primary external reference: UniProt: Q9NYY1-PRO_0000015381

DNA Sequence (3 results from a total of 4)

Identifier: R-HSA-8877337
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: ENSEMBL: ENSG00000109471
Identifier: R-HSA-6790030
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: ENSEMBL: ENST00000619177
Identifier: R-HSA-8948474
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: ENSEMBL: ENSG00000162594

Set (1 results from a total of 1)

Identifier: R-HSA-453105
Species: Homo sapiens
Compartment: cytosol

Reaction (3 results from a total of 119)

Identifier: R-HSA-450063
Species: Homo sapiens
Compartment: plasma membrane
Recruitment of the IL-2R gamma chain forms a very stable quaternary complex, capable of signaling. The IL-2 gamma chain further retards IL-2 dissociation so that the rate of IL-2 dissociation from the complex is three times slower than the rate of internalization of the complex (t1/2 55= 45 min vs. 15 min). Therefore, the complex continues to signal as long as it remains on the cell surface.
Identifier: R-HSA-452100
Species: Homo sapiens
Compartment: cytosol, plasma membrane
Following IL2 stimulation of IL2R, Shc is known to be tyrosine phosphorylated (Zhu et al. 1994). The identity of the kinase is uncertain (Gesbert et al. 1998); JAK1 may be responsible but this has not been demonstrated, another candidate is Lck.

Following IL-3 treatment, Shc becomes tyrosyl phoshorylated at 3 sites, Y427 (Salcini et al. 1994), Y349 and Y350 (Gotoh et al. 1996). Y427 mediates the subsequent association with Grb2 (Salcini et al. 1994).

Numbering here refers to Uniprot P29353 where the p66 isoform has been selected as the canonical form. Literature references used here refer to the p52 isoform which lacks the first 110 residues, so Y427 is referred to as Y317 in Salcini et al. 1994, Y349 and Y350 as Y239 and Y240 in Gotoh et al. 1996.
Identifier: R-HSA-8877338
Species: Homo sapiens
Compartment: nucleoplasm
The complex of CBFB and RUNX1 (AML1) binds to the promoter of the IL2 gene in cooperation with NFATC2 (NFAT1). NFAT response element is adjacent to RUNX1 response element in the IL2 promoter (Ono et al. 2007).

Complex (3 results from a total of 136)

Identifier: R-HSA-450065
Species: Homo sapiens
Compartment: plasma membrane
Identifier: R-HSA-538993
Species: Homo sapiens
Compartment: plasma membrane
Identifier: R-HSA-451939
Species: Homo sapiens
Compartment: plasma membrane

Pathway (3 results from a total of 7)

Identifier: R-HSA-389513
Species: Homo sapiens
CTLA4 is one of the best studied inhibitory receptors of the CD28 superfamily. CTLA4 inhibits T cell activation by reducing IL2 production and IL2 expression, and by arresting T cells at the G1 phase of the cell cycle. CTLA-4 expressed by a T cell subpopulation exerts a dominant control on the proliferation of other T cells, which limits autoreactivity. CTLA4 also blocks CD28 signals by competing for the ligands B71 and B72 in the limited space between T cells and antigenpresenting cells. Though the mechanism is obscure, CTLA4 may also propagate inhibitory signals that actively counter those produced by CD28. CTLA4 can also function in a ligand-independent manner.
CTLA-4 regulates the activation of pathogenic T cells by directly modulating T cell receptor signaling (i.e. TCR-zeta chain phosphorylation) as well as downstream biochemical signals (i.e. ERK activation). The cytoplasmic region of CTLA4 contains a tyrosine motif YVKM and a proline rich region. After TCR stimulation, it undergoes tyrosine phosphorylation by src kinases, inducing surface retention.
Identifier: R-HSA-8983432
Species: Homo sapiens
The high affinity Interleukin-15 receptor is a heterotrimer of Interleukin-15 receptor subunit alpha (IL15RA), Interleukin-2 receptor subunit beta (IL2RB, CD122) and Cytokine receptor common subunit gamma (IL2RG, CD132). IL2RB and IL2RG are also components of the Interleukin-2 (IL2) receptor. Treatment of human T cells with Interleukin-15 (IL15) results in tyrosine phosphorylation of Tyrosine-protein kinase JAK1 (JAK1, Janus kinase 1) and Tyrosine-protein kinase JAK3 (JAK3, Janus kinase 3) (Johnston et al. 1995, Winthrop 2017). IL15 can signal by a process termed 'trans presentation', where IL15 bound by IL15 on one cell is trans-presented to IL2RB:IL2RG on another cell (Dubois et al. 2002) but can also participate in more 'traditional' cis signaling (Wu et al. 2008, Mishra et al. 2014) where all the three receptors are present on the same cell. Stimulation of lymphocytes by IL15 release MAPK activation through GAB2/SHP2/SHC (GRB2-associated-binding protein 2/Tyrosine-protein phosphatase non-receptor type 11/SHC transforming protein 1 or 2) cascade activation (Gadina et al. 2000).
Identifier: R-HSA-8877330
Species: Homo sapiens
The complex of CBFB and RUNX1 (AML1) controls transcription of the FOXP3 gene. FOXP3 is a transcription factor that acts as a key regulator of development and function of regulatory T lymphocytes (Tregs). Tregs are CD25+CD4+ T lymphocytes involved in suppression of aberrant immune responses seen in autoimmune diseases and allergies. FOXP3 can bind to RUNX1 and control transcriptional activity of the RUNX1:CBFB complex. RUNX1 stimulates transcription of IL2 and IFNG1 (IFN-gamma), and the expression of these two genes is repressed upon binding of FOXP3 to RUNX1. The complex of FOXP3 and RUNX1, on the other hand, stimulates transcription of cell surface markers of Tregs, such as CD25, CTLA-4 and GITR. In the absence of FOXP3, RUNX1 represses transcription of these genes (Shevach 2000, Maloy and Powrie 2001, Sakaguchi 2004, Ono et al. 2007, Kitoh et al. 2009).
The RUNX1:CBFB complex directly stimulates transcription of the CR1 gene, encoding Complement receptor type 1 (CD35) (Kim et al. 1999, Rho et al. 2002). Expression of CR1 on the surface of activated T cells contributes to generation of Tregs (Torok et al. 2015).

Icon (2 results from a total of 2)

Species: Homo sapiens
Curator: Steve Jupe
Designer: Cristoffer Sevilla
IL2R icon
Interleukin 2 receptor subunit A, B or G
Species: Homo sapiens
Curator: Steve Jupe
Designer: Cristoffer Sevilla
IL20R icon
Interleukin 20 receptor subunit A or B
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