Search results for ITGA4

Showing 11 results out of 11

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Species

Types

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Protein (1 results from a total of 1)

Identifier: R-HSA-198007
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: ITGA4: P13612

DNA Sequence (1 results from a total of 1)

Identifier: R-HSA-8949356
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: ENSEMBL: ENSG00000115232

Complex (3 results from a total of 3)

Identifier: R-HSA-198201
Species: Homo sapiens
Compartment: plasma membrane
Identifier: R-HSA-9679842
Species: Homo sapiens
Compartment: plasma membrane
Identifier: R-HSA-8949328
Species: Homo sapiens
Compartment: nucleoplasm

Set (2 results from a total of 2)

Identifier: R-HSA-8949353
Species: Homo sapiens
Compartment: plasma membrane
Identifier: R-HSA-8949354
Species: Homo sapiens
Compartment: nucleoplasm

Reaction (3 results from a total of 3)

Identifier: R-HSA-9679740
Species: Homo sapiens
Compartment: plasma membrane, extracellular region
Integrins are the receptors that mediate cell adhesion to the extracellular matrix (ECM). They are involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. Integrin alpha-4 (ITGA4) is a receptor for fibronectin. ITGA4 functions as a heterodimer of an alpha subunit and the beta subunit of either the beta-1 chain or the beta-7 chain (ITGA4:ITGB1 shown here).

Natalizumab (Tysabri) is a humanised monoclonal antibody against the cell adhesion molecule α4-integrin. It is a medication used to treat multiple sclerosis and Crohn's disease (No authors 2004). It binds to the α4-subunit of α4b1 and α4b7 integrins expressed on the surface of all leukocytes except neutrophils, and inhibits the α4-mediated adhesion of leukocytes to their counter-receptors. This is thought to reduce the ability of inflammatory immune cells to attach to and pass through the cell layers lining the intestines and blood–brain barrier (Rice et al. 2005).
Identifier: R-HSA-8949343
Species: Homo sapiens
Compartment: nucleoplasm, plasma membrane
Transcription of the ITGAL (CD11a) gene, is stimulated by binding of RUNX3, presumably in complex with CBFB, to the ITGAL promoter. ITGAL is a leukocyte integrin involved in transendothelial migration of leukocytes during immune and inflammatory responses as well as co-stimulation of T cells. RUNX3, as well as RUNX1, positively regulate integrin alpha 4 (ITGA4, also known as CD49d) expression. A RUNX binding site exists in the ITGA4 promoter, but the direct regulation by RUNX transcription factors has not been demonstrated (Domniguez-Soto et al. 2005).
Identifier: R-HSA-8949335
Species: Homo sapiens
Compartment: nucleoplasm
RUNX3, presumably in complex with CBFB, binds the RUNX response element in the promoter of the ITGAL (CD11a) gene, encoding leukocyte integrin involved in transendothelial migration of leukocytes during immune and inflammatory responses as well as co-stimulation of T cells (Puig-Kroger et al. 2003, Dominguez-Soto et al. 2005). RUNX3, as well as RUNX1, may also be involved in regulation of integrin alpha 4 (ITGA4, also known as CD49d) expression. A RUNX binding site exists in the ITGA4 promoter, but the direct binding of RUNX transcription factors has not been demonstrated (Domniguez-Soto et al. 2005).

Pathway (1 results from a total of 1)

Identifier: R-HSA-8949275
Species: Homo sapiens
RUNX3-mediated transcription regulates development of immune system cells. RUNX3 is necessary for the development of innate lymphoid cells (ILCs) of ILC1 and ILC3 lineages, which reside in the mucosa and are involved in response to external pathogens. RUNX3 exerts its role in the development of ILC1 and ILC3 lineages by stimulating expression of the RORC (RORgamma) gene, encoding nuclear retinoid-related orphan receptor-gamma (Ebihara et al. 2015).
RUNX3 regulates transcription of integrin genes ITGAL (CD11a) and ITGA4 (CD49d), involved in transendothelial migration of leukocytes during immune and inflammatory responses as well as co-stimulation of T cells (Domniguez-Soto et al. 2005). The RUNX3 splicing isoform p33 lacks the Runt domain and is unable to transactivate integrin genes. The p33 isoform is induced during maturation of monocyte-derived dendritic cells (MDDC), leading to reduced expression of genes involved in inflammatory responses, such as IL8 (interleukin-8) (Puig-Kroger et al. 2010).
RUNX3 positively regulates transcription of the SPP1 (osteopontin) gene, which contributes to invasiveness of pancreatic cancer cells (Whittle et al. 2015).
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