Search results for ITGA4

Showing 3 results out of 3

×

Species

Types

Compartments

Reaction types

Search properties

Species

Types

Compartments

Reaction types

Search properties

Reaction (3 results from a total of 3)

Identifier: R-HSA-9679740
Species: Homo sapiens
Compartment: plasma membrane, extracellular region
Integrins are the receptors that mediate cell adhesion to the extracellular matrix (ECM). They are involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. Integrin alpha-4 (ITGA4) is a receptor for fibronectin. ITGA4 functions as a heterodimer of an alpha subunit and the beta subunit of either the beta-1 chain or the beta-7 chain (ITGA4:ITGB1 shown here).

Natalizumab (Tysabri) is a humanised monoclonal antibody against the cell adhesion molecule α4-integrin. It is a medication used to treat multiple sclerosis and Crohn's disease (No authors 2004). It binds to the α4-subunit of α4b1 and α4b7 integrins expressed on the surface of all leukocytes except neutrophils, and inhibits the α4-mediated adhesion of leukocytes to their counter-receptors. This is thought to reduce the ability of inflammatory immune cells to attach to and pass through the cell layers lining the intestines and blood–brain barrier (Rice et al. 2005).
Identifier: R-HSA-8949343
Species: Homo sapiens
Compartment: nucleoplasm, plasma membrane
Transcription of the ITGAL (CD11a) gene, is stimulated by binding of RUNX3, presumably in complex with CBFB, to the ITGAL promoter. ITGAL is a leukocyte integrin involved in transendothelial migration of leukocytes during immune and inflammatory responses as well as co-stimulation of T cells. RUNX3, as well as RUNX1, positively regulate integrin alpha 4 (ITGA4, also known as CD49d) expression. A RUNX binding site exists in the ITGA4 promoter, but the direct regulation by RUNX transcription factors has not been demonstrated (Domniguez-Soto et al. 2005).
Identifier: R-HSA-8949335
Species: Homo sapiens
Compartment: nucleoplasm
RUNX3, presumably in complex with CBFB, binds the RUNX response element in the promoter of the ITGAL (CD11a) gene, encoding leukocyte integrin involved in transendothelial migration of leukocytes during immune and inflammatory responses as well as co-stimulation of T cells (Puig-Kroger et al. 2003, Dominguez-Soto et al. 2005). RUNX3, as well as RUNX1, may also be involved in regulation of integrin alpha 4 (ITGA4, also known as CD49d) expression. A RUNX binding site exists in the ITGA4 promoter, but the direct binding of RUNX transcription factors has not been demonstrated (Domniguez-Soto et al. 2005).
Cite Us!