Search results for LDHD

Showing 6 results out of 6

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Protein (4 results from a total of 4)

Identifier: R-HSA-1299437
Species: Homo sapiens
Compartment: mitochondrial inner membrane
Primary external reference: UniProt: LDHD: Q86WU2
Identifier: R-HSA-8986145
Species: Homo sapiens
Compartment: mitochondrial matrix
Primary external reference: UniProt: Q86WU2
Identifier: R-HSA-1267974
Species: Homo sapiens
Compartment: mitochondrial intermembrane space
Primary external reference: UniProt: Q86WU2
Identifier: R-HSA-1299433
Species: Homo sapiens
Compartment: mitochondrial inner membrane
Primary external reference: UniProt: Q86WU2
The N-terminus of LDLD is predicted by software.

Reaction (2 results from a total of 2)

Identifier: R-HSA-1299482
Species: Homo sapiens
Compartment: mitochondrial inner membrane
As inferred from the yeast TIM23 complex, the human TIMM23 complex resides in the inner membrane of the mitochondrion and transfers precursor proteins to the inner membrane. The presequences of proteins targeted to the inner membrane are transferred to the matrix where they are cleaved. Sequences in the mature regions of the proteins then interact with the TIMM23 complex to halt transfer across the inner membrane and the proteins are released laterally into the inner membrane. TIMM21 is required.
In yeast experimentally verified substrates of the TIM23 complex targeted to the inner membrane include CYB2, DLD (LDHD in human), ATP9 (ATP5G1 in human), COQ2, TIM54 (TIMM54 in human), COX4, COX5A, and ATP2 (ATP5B in human). Many other inner membrane proteins are believed to be substrates of the TIMM23 complex.
Identifier: R-HSA-1299487
Species: Homo sapiens
Compartment: mitochondrial inner membrane, mitochondrial intermembrane space
As inferred from the yeast TIM23 complex, the human TIMM23 complex resides in the inner membrane of the mitochondrion and transfers precursor proteins to the inner membrane. The TIMM23 complex appears to adopt different configurations (and perhaps different subunit compositions) depending on whether the substrate is destined for the inner membrane or the matrix. Here we refer to the TIMM23 SORT complex as the configuration that delivers inner membrane proteins. The TIMM21 subunit is required for this activity. In yeast, the N-terminal presequences of precursors first interact with TIM50 and TIM23 (TIMM50 and TIMM23 in human, Zhang et al. 2013). The TIM17 and TIM23 subunits (TIMM17 and TIMM23 in human) form a channel and are required to initiate translocation of precursors.
In yeast experimentally verified substrates of the TIM23 SORT complex targeted to the inner membrane include CYB2, DLD (LDHD in human), ATP9 (ATP5G1 in human), COQ2, TIM54 (TIMM54 in human), COX4, COX5A, and ATP2 (ATP5B in human). Many other inner membrane proteins are believed to be substrates of the TIMM23 complex.
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