Search results for LTA4H

Showing 15 results out of 16

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Protein (4 results from a total of 4)

Identifier: R-HSA-266022
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: LTA4H: P09960
Identifier: R-HSA-6803303
Species: Homo sapiens
Compartment: ficolin-1-rich granule lumen
Primary external reference: UniProt: LTA4H: P09960
Identifier: R-HSA-6803343
Species: Homo sapiens
Compartment: extracellular region
Primary external reference: UniProt: P09960
Identifier: R-HSA-6803308
Species: Homo sapiens
Compartment: tertiary granule lumen
Primary external reference: UniProt: P09960

Reaction (10 results from a total of 11)

Identifier: R-HSA-266072
Species: Homo sapiens
Compartment: cytosol
Leukotriene A4 hydrolase (LTA4H) is a monomeric, soluble enzyme that catalyzes the hydrolysis of the allylic epoxide leukotriene A4 (LTA4) to the dihydroxy acid leukotriene B4 (LTB4) (Radmark et al. 1984, McGee & Fitzpatrick 1985).
Identifier: R-HSA-9018862
Species: Homo sapiens
Compartment: cytosol
Leukotriene A4 hydrolase (LTA4H) is a monomeric, soluble enzyme that uses a Zn2+ cofactor to catalyse the hydrolysis of the allylic epoxide leukotriene A4 (LTA4) (McGee & Fitzpatrick 1985). LTA4H can also catalyse the hydrolysis of 5S,6S-epoxy-18(S)-HEPE to the 18(S) stereoisomer of resolvin E1 (18(S)-RvE1) (Oh et al. 2011). The E-resolvins are anti-inflammatory, pro-resolving, and non-phlogistic (that is, they mediate the clearance of leukocytes without eliciting an inflammatory response) (Serhan et al. 2008).
Identifier: R-HSA-9018877
Species: Homo sapiens
Compartment: cytosol
Leukotriene A4 hydrolase (LTA4H) is a monomeric, soluble enzyme that uses a Zn2+ cofactor to catalyse the hydrolysis of the allylic epoxide leukotriene A4 (LTA4) (McGee & Fitzpatrick 1985). LTA4H can also catalyse the hydrolysis of 5S,6S-epoxy-18(R)-HEPE to the 18(R) stereoisomer of resolvin E1 (18(R)-RvE1) (Oh et al. 2011). The E-resolvins are antiinflammatory, pro-resolving, and non-phlogistic (that is, they mediate the clearance of leukocytes without eliciting an inflammatory response) (Serhan et al. 2008).
Identifier: R-HSA-9020252
Species: Homo sapiens
Compartment: cytosol
Leukotriene A4 hydrolase (LTA4H) is a monomeric, soluble enzyme that uses a Zn2+ cofactor to catalyse the hydrolysis of the allylic epoxide leukotriene A4 (LTA4) (McGee & Fitzpatrick 1985). LTA4H can also catalyse the hydrolysis of 7S(8)-epoxy-17(R)-hydroxydocosahexaenoic acid (7S(8)-epoxy-17(R)-HDHA) to the trihydroxydocosahexaenoic acids 7(S), 8(R), 17(R)-triHDHA and 7(S), 16(R), 17(R)-triHDHA (AT-RvD1 and AT-RvD2 respectively) (Sun et al. 2007, Spite et al. 2009, Serhan et al. 2002). The D-resolvins are anti-inflammatory, pro-resolving, and non-phlogistic (that is, they mediate the clearance of leukocytes without eliciting an inflammatory response) (Serhan et al. 2008).
Identifier: R-HSA-9020270
Species: Homo sapiens
Compartment: cytosol
Leukotriene A4 hydrolase (LTA4H) is a monomeric, soluble enzyme that uses a Zn2+ cofactor to catalyse the hydrolysis of the allylic epoxide leukotriene A4 (LTA4) (McGee & Fitzpatrick 1985). LTA4H can also catalyse the hydrolysis of 4S(5)-epoxy-17(R)-hydroxydocosahexaenoic acid (4S(5)-epoxy-17(R)-HDHA) to the trihydroxydocosahexaenoic acids 4(S), 11(R), 17(R)-triHDHA and 4(S), 5(R), 17(R)-triHDHA (AT-RvD3 and AT-RvD4 respectively) (Dalli et al. 2013, Serhan et al. 2002, Winkler et al. 2013, 2016). The D-resolvins are anti-inflammatory, pro-resolving, and non-phlogistic (that is, they mediate the clearance of leukocytes without eliciting an inflammatory response) (Serhan et al. 2008).
Identifier: R-HSA-9020257
Species: Homo sapiens
Compartment: cytosol
Leukotriene A4 hydrolase (LTA4H) is a monomeric, soluble enzyme that uses a Zn2+ cofactor to catalyse the hydrolysis of the allylic epoxide leukotriene A4 (LTA4) (McGee & Fitzpatrick 1985). LTA4H may also be able to catalyse the hydrolysis of 17R(6)-epoxy-docosahexaenoic acid (17R(16)-epoxy-DHA) to 10(R),17(R)-dihydroxydocosa-4Z,7Z,11E,13E,15Z,19Z-hexaenoic acid (aspirin-triggered (neuro)protectin D1, AT-(N)PD1) (Serhan et al. 2011). In human cells, AT-(N)PD1 decreased PMN migration as well as enhancing efferocytosis of apoptotic human PMN by macrophages, indicating AT-(N)PD1 as a potent anti-inflammatory proresolving molecule (Serhan et al. 2011).
Identifier: R-HSA-9020253
Species: Homo sapiens
Compartment: cytosol
Leukotriene A4 hydrolase (LTA4H) is a monomeric, soluble enzyme that uses a Zn2+ cofactor to catalyse the hydrolysis of the allylic epoxide leukotriene A4 (LTA4) (McGee & Fitzpatrick 1985). LTA4H can also catalyse the hydrolysis of 4S(5)-epoxy-17(S)-hydroxydocosahexaenoic acid (4S(5)-epoxy-17(S)-HDHA) to the trihydroxydocosahexaenoic acids 4(S), 11(R), 17(S)-triHDHA and 4(S), 5(R), 17(S)-triHDHA (RvD3 and RvD4 respectively) (Dalli et al. 2013, Serhan et al. 2002, Winkler et al. 2013, 2016). The D-resolvins are anti-inflammatory, pro-resolving, and non-phlogistic (that is, they mediate the clearance of leukocytes without eliciting an inflammatory response) (Serhan et al. 2008).
Identifier: R-HSA-9020258
Species: Homo sapiens
Compartment: cytosol
Leukotriene A4 hydrolase (LTA4H) is a monomeric, soluble enzyme that uses a Zn2+ cofactor to catalyse the hydrolysis of the allylic epoxide leukotriene A4 (LTA4) (McGee & Fitzpatrick 1985). LTA4H can also catalyse the hydrolysis of 7S(8)-epoxy-17(S)-hydroxydocosahexaenoic acid (7S(8)-epoxy-17(S)-HDHA) to the trihydroxydocosahexaenoic acids 7(S), 8(R), 17(S)-triHDHA and 7(S), 16(R), 17(S)-triHDHA (RvD1 and RvD2 respectively) (Sun et al. 2007, Spite et al. 2009, Serhan et al. 2002). The D-resolvins are anti-inflammatory, pro-resolving, and non-phlogistic (that is, they mediate the clearance of leukocytes without eliciting an inflammatory response) (Serhan et al. 2008).
Identifier: R-HSA-9024890
Species: Homo sapiens
Compartment: cytosol
Leukotriene A4 hydrolase (LTA4H) is a monomeric, soluble enzyme that uses a Zn2+ cofactor to catalyse the hydrolysis of the allylic epoxide leukotriene A4 (LTA4) (McGee & Fitzpatrick 1985). When produced in neural tissue, where it affords potent tissue protective actions, this docsanoid is called neuroprotectin D1 (NPD1).
Identifier: R-HSA-9024983
Species: Homo sapiens
Compartment: cytosol
In macrophages, lipoxygenase 12 (ALOX12:Fe2+) may abstract hydrogen from 14(S)-hydroperoxy-docosaheaenoic acid (14(S)-Hp-DHA) to form 13(S),14(S)-epoxy-DHA (Serhan et al. 2009, Dalli et al. 2013, Deng et al. 2014). This epoxy product is a central intermediate in maresin MaR1 and MaR2 and maresin conjugates in tissue regeneration (MCTR) biosyntheses (Dalli et al. 2016) as well as possessing potent proresolving activity (Dalli et al 2013).

Complex (1 results from a total of 1)

Identifier: R-HSA-266038
Species: Homo sapiens
Compartment: cytosol
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