Search results for LYN

Showing 20 results out of 128

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Species

Types

Compartments

Reaction types

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Protein (3 results from a total of 8)

LYN

Identifier: R-HSA-354251
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: LYN: P07948

LYN

Identifier: R-HSA-197943
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: LYN: P07948
Identifier: R-HSA-2454229
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: LYN: P07948

Interactor (3 results from a total of 3)

LYN

Identifier: P07948-1
Species: Homo sapiens
Primary external reference: UniProt: P07948-1
Identifier: P14317
Species: Homo sapiens
Primary external reference: UniProt: P14317
Identifier: P0DP58-2
Species: Homo sapiens
Primary external reference: UniProt: P0DP58-2

Set (3 results from a total of 7)

Identifier: R-HSA-5621132
Species: Homo sapiens
Compartment: cytosol
Identifier: R-HSA-9606888
Species: Homo sapiens
Compartment: plasma membrane
Identifier: R-HSA-2892443
Species: Homo sapiens
Compartment: plasma membrane

Reaction (3 results from a total of 63)

Identifier: R-HSA-5690702
Species: Homo sapiens
Compartment: plasma membrane
After ligation of membrane-bound IgM, CD22 is quickly tyrosine phosphorylated on its cytoplasmic ITIM sequence (immunoreceptor tyrosine-based inhibition motif). The tyrosine kinase involved in CD22 phosphorylation is LYN, a member of the Src kinase family (Smith et al. 1998). The CD22 cytoplasmic tail contains six tyrosines, three of which belong to the ITIM sequence (Nitschke & Tsubata 2004).
Identifier: R-HSA-2730862
Species: Homo sapiens
Compartment: plasma membrane, cytosol
LYN localized in lipid rafts undergoes an intermolecular autophosphorylation at tyrosine 396. This residue is present in the activation loop, and its phosphorylation promotes LYN kinase activity.
Identifier: R-HSA-432295
Species: Homo sapiens
Compartment: cytosol, plasma membrane
Fyn and Lyn constitutively associate with GPVI-Fc epsilon R1 gamma in platelets. The proline-rich region of GPVI is required for this interaction.

Complex (3 results from a total of 30)

Identifier: R-HSA-3928499
Species: Homo sapiens
Compartment: plasma membrane
Identifier: R-HSA-9006300
Species: Homo sapiens
Compartment: plasma membrane
Identifier: R-HSA-9006298
Species: Homo sapiens
Compartment: plasma membrane

Person (1 results from a total of 1)

Authored Pathways: 0
Reviewed Pathways: 3
Authored Reactions: 0
Reviewed Reactions: 31

Pathway (3 results from a total of 15)

Identifier: R-HSA-389356
Species: Homo sapiens
In naive T cells, CD28 costimulation enhances cell cycle entry, potently stimulates expression of both the mitogenic lymphokine interleukin-2 (IL-2) and its receptor, and stimulates the activation of an antiapoptotic program. CD28 engages with one or both members of the B7 receptor family, B7.1 and B7.2. Upon ligand binding the tyrosines and proline-rich motifs present in the cytoplasmic tail of CD28 are phosphorylated by Lck or Fyn. Upon phosphorylation CD28 recruits and induces phosphorylation and activation of a more restricted set of intracellular signaling components that, together with those mobilized by the TCR, contribute to convert membrane-based biochemical and biophysical changes into gene activation events. Proteins like PI3K, Vav-1, Tec and Itk kinases, AKT, and the Dok-1 adaptor have been identified as elements of the CD28 signaling pathway by biochemical or genetic approaches or both.
Identifier: R-HSA-5579000
Species: Homo sapiens
Cytochrome P450 1B1 (CYP1B1) can oxidise a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics as well as activating a range of procarcinogens. A specific substrate is the female sex hormone estradiol-17beta (EST17b) which is 4-hydroxylated to 4-hydroxyestradiol-17beta 4OH-EST17b). Defects in CYP1B1 can cause glaucoma disorders such as Glaucoma 3, primary congenital, A (GLC3A; MIM:231300), Glaucoma, primary open angle (POAG; MIM:137760), Glaucoma 1, open angle, A (GLC1A; MIM:137750) and Peters anomaly (PAN; MIM:604229). These disorders cause a progressive optic neuropathy characterised by visual field defects that ultimately lead to irreversible blindness (Li et al. 2011, Sarfarazi et al. 2003, Vincent et al. 2001).
Identifier: R-HSA-114604
Species: Homo sapiens
The GPVI receptor is a complex of the GPVI protein with Fc epsilon R1 gamma (FcR). The Src family kinases Fyn and Lyn constitutively associate with the GPVI-FcR complex in platelets and initiate platelet activation through phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) in the FcR gamma chain, leading to binding and activation of the tyrosine kinase Syk. Downstream of Syk, a series of adapter molecules and effectors lead to platelet activation.

The GPVI receptor signaling cascade is similar to that of T- and B-cell immune receptors, involving the formation of a signalosome composed of adapter and effector proteins. At the core of the T-cell receptor signalosome is the transmembrane adapter LAT and two cytosolic adapters SLP-76 and Gads. While LAT is essential for signalling to PLCgamma1 downstream of the T-cell receptor, the absence of LAT in platelets only impairs the activation of PLCgamma2, the response to collagen and GPVI receptor ligands remains sufficient to elicit a full aggregation response. In contrast, GPVI signalling is almost entirely abolished in the absence of SLP-76.

Icon (1 results from a total of 1)

LYN

Species: Homo sapiens
Curator: Steve Jupe
Designer: Cristoffer Sevilla
LYN icon
Tyrosine-protein kinase Lyn
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