Search results for MAP1LC3B

Showing 16 results out of 19

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Protein (3 results from a total of 3)

Identifier: R-HSA-5205651
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: MAP1LC3B: Q9GZQ8
Identifier: R-HSA-5683641
Species: Homo sapiens
Compartment: autophagosome membrane
Primary external reference: UniProt: Q9GZQ8
Identifier: R-HSA-5682674
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: Q9GZQ8

Reaction (6 results from a total of 9)

Identifier: R-HSA-9687109
Species: Homo sapiens
Compartment: cytosol
It is known that non-structural proteins (nsp) in SARS-CoV viruses induce the formation of ER-bound double membrane vesicles (DMV) in host cells post infection. These DMVs are decorated with microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B) proteins that are involved in autophagosome formation. However, there is no evidence that DMVs are recruited to the autophagy machinery. Studies show that in some cells sars8b (8b) colocalizes with MAP1LC3B. However, little is known about underlying molecular mechanisms (Shi C S. et al 2019).
Identifier: R-HSA-9687121
Species: Homo sapiens
Compartment: cytosol
The replicase polyprotein 1a of the human severe acute respiratory syndrome coronavirus (SARS-CoV) is post-translationally cleaved by virally encoded proteases to generate non-structural proteins (nsps). Viral nsps induce the formation of ER-bound double membrane vesicles (DMV) in host cells post infection. These DMVs are decorated with microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B) proteins that are involved in autophagosome formation. However, there is no evidence that DMVs are recruited to the autophagy machinery. Immunofluorescence studies show that nsp8 colocalizes with MAP1LC3B suggesting a binding event (Prentice E. et al 2004).
Identifier: R-HSA-9664867
Species: Homo sapiens
Compartment: peroxisomal membrane
Once recruited to the peroxisomal membrane, Next to BRCA1 gene 1 protein (NBR1) can bind with Microtubule associated proteins 1A/1B light chain 3B (MAP1LC3B)/LC3 with the help of its LC3 interacting region (LIR) domain (Kirkin V et al. 2009). This targets the peroxisomes to the autophagosomes and the degradation process starts.
Identifier: R-HSA-9694580
Species: Homo sapiens
Compartment: cytosol
This COVID‑19 event has been created by a combination of computational inference from SARS-CoV-1 data (https://reactome.org/documentation/inferred-events) and manual curation, as described in the summation for the overall SARS-CoV-2 infection pathway.

The replicase polyprotein 1a of the human severe acute respiratory syndrome coronavirus is post-translationally cleaved by virally encoded proteases to generate non-structural proteins (nsps). Viral nsps induce the formation of ER-bound double membrane vesicles (DMV) in host cells post infection. These DMVs are decorated with host microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B) proteins that are involved in autophagosome formation. However, there is no evidence that DMVs are recruited to the autophagy machinery. Immunofluorescence studies show that nsp8 colocalizes with MAP1LC3B suggesting a binding event (Prentice E. et al 2004).
Identifier: R-HSA-9664880
Species: Homo sapiens
Compartment: peroxisomal membrane
Autophagic receptors, Next to BRCA1 gene 1 protein (NBR1) and Sequestosome 1 (SQSTM1) cooperate to bind and recruit ubiquitinated peroxisomes to the autophagy machinery. NBR1 and SQSTM1 have similar protein domain architecture and bind to Microtubule associated proteins 1A/1B light chain 3B (MAP1LC3B)/LC3 via an LC3 interacting region (LIR) (Kirkin V et al. 2009). Subsequently, peroxisomes are engulfed within the autophagosome and degraded.
Identifier: R-HSA-9664855
Species: Homo sapiens
Compartment: peroxisomal membrane
Sequestosome 1 (SQSTM1) is an autophagic receptor that recruits ubiquitinated cargo to the autophagosome. SQSTM1 contains a ubiquitin associated (UBA) domain that binds to monoubiquitinated Peroxisomal targeting signal 1 receptor (PEX5) in the peroxisome and an LC3 interacting region (LIR) that binds to Microtubule associated proteins 1A/1B light chain 3B (MAP1LC3B)/LC3 associated with the nascent autophagosome (Pankiv S et al. 2007). Subsequently, the peroxisome is degraded by the autophagy machinery.

Complex (5 results from a total of 5)

Identifier: R-HSA-9665173
Species: Homo sapiens
Compartment: peroxisomal membrane
Identifier: R-HSA-9687117
Species: Homo sapiens
Compartment: cytosol
Identifier: R-HSA-9694566
Species: Homo sapiens
Compartment: cytosol
This COVID-19 Complex instance was generated via electronic inference from a curated CoV-1 (Human SARS coronavirus) Reactome instance. In Reactome, inference is the process used to automatically create orthologous Pathways, Reactions and PhysicalEntities from our expertly curated data (https://reactome.org/documentation/inferred-events).
Identifier: R-HSA-9665167
Species: Homo sapiens
Compartment: peroxisomal membrane
Identifier: R-HSA-9665166
Species: Homo sapiens
Compartment: peroxisomal membrane

Set (1 results from a total of 1)

Identifier: R-HSA-8854613
Species: Homo sapiens
Compartment: autophagosome membrane

Icon (1 results from a total of 1)

Species: Homo sapiens
A disk-like structure that expands, rounds up into a cup-shaped structure, and eventually closes around its cargo (for example cytoplasmic components) to become an autophagosome or Cvt vesicle
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