Search results for MET

Showing 19 results out of 832

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Species

Types

Compartments

Reaction types

Search properties

Protein (2 results from a total of 35)

MET

Identifier: R-HSA-419603
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: MET: P08581
Identifier: R-HSA-8874689
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: MET: P08581

DNA Sequence (1 results from a total of 1)

Identifier: R-HSA-9005531
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: ENSEMBL: ENSEMBL:ENSG00000105976

Pathway (2 results from a total of 153)

Identifier: R-HSA-6806834
Species: Homo sapiens
MET is a receptor tyrosine kinase (RTK) (Cooper et al. 1984, Park et al. 1984) activated by binding to its ligand, Hepatocyte growth factor/Scatter factor (HGF/SF) (Bottaro et al. 1991, Naldini et al. 1991). Similar to other related RTKs, such as EGFR, ligand binding induces MET dimerization and trans-autophosphorylation, resulting in the active MET receptor complex (Ferracini et al. 1991, Longati et al. 1994, Rodrigues and Park 1994, Kirchhofer et al. 2004, Stamos et al. 2004, Hays and Watowich 2004). Phosphorylated tyrosines in the cytoplasmic tail of MET serve as docking sites for binding of adapter proteins, such as GRB2, SHC1 and GAB1, which trigger signal transduction cascades that activate PI3K/AKT, RAS, STAT3, PTK2, RAC1 and RAP1 signaling (Ponzetto et al. 1994, Pelicci et al. 1995, Weidner et al. 1995, Besser et al. 1997, Shen and Novak 1997, Beviglia and Kramer 1999, Rodrigues et al. 2000, Sakkab et al. 2000, Schaeper et al. 2000, Lamorte et al. 2002, Wang et al. 2002, Chen and Chen 2006, Palamidessi et al. 2008, Chen et al. 2011, Murray et al. 2014).
Activation of PLC gamma 1 (PLCG1) signaling by MET remains unclear. It has been reported that PLCG1 can bind to MET directly (Ponzetto et al. 1994) or be recruited by phosphorylated GAB1 (Gual et al. 2000). Tyrosine residue Y307 of GAB1 that serves as docking sites for PLCG1 may be phosphorylated either by activated MET (Watanabe et al. 2006) or SRC (Chan et al. 2010). Another PCLG1 docking site on GAB1, tyrosine residue Y373, was reported as the SRC target, while the kinase for the main PLCG1 docking site, Y407 of GAB1, is not known (Chan et al. 2010).
Signaling by MET promotes cell growth, cell survival and motility, which are essential for embryonic development (Weidner et al. 1993, Schmidt et al. 1995, Uehara et al. 1995, Bladt et al. 1995, Maina et al. 1997, Maina et al. 2001, Helmbacher et al. 2003) and tissue regeneration (Huh et al. 2004, Borowiak et al. 2004, Liu 2004, Chmielowiec et al. 2007). MET signaling is frequently aberrantly activated in cancer, through MET overexpression or activating MET mutations (Schmidt et al. 1997, Pennacchietti et al. 2003, Smolen et al. 2006, Bertotti et al. 2009).
Considerable progress has recently been made in the development of HGF-MET inhibitors in cancer therapy. These include inhibitors of HGF activators, HGF inhibitors and MET antagonists, which are protein therapeutics that act outside the cell. Kinase inhibitors function inside the cell and have constituted the largest effort towards MET-based therapeutics (Gherardi et al. 2012).
Pathogenic bacteria of the species Listeria monocytogenes, exploit MET receptor as an entryway to host cells (Shen et al. 2000, Veiga and Cossart 2005, Neimann et al. 2007).
For review of MET signaling, please refer to Birchmeier et al. 2003, Trusolino et al. 2010, Gherardi et al. 2012, Petrini 2015.
Identifier: R-HSA-8875656
Species: Homo sapiens
Activated MET receptor is subject to recycling from the plasma membrane through the endosomal compartment and back to the plasma membrane (Peschard et al. 2001, Hammond et al. 2001, Petrelli et al. 2002). In the recycling process, activated MET receptor is endocytosed, and the GGA3 protein directs it, via a largely unknown mechanism, through the RAB4 positive endosomal compartments back to the plasma membrane (Parachoniak et al. 2011). Endosomal signaling by MET during the recycling process appears to play an important role in sustained activation of ERK1/ERK2 (MAPK3/MAPK1) and STAT3 downstream of MET (Kermorgant and Parker 2008).

Complex (2 results from a total of 105)

Identifier: R-HSA-9658856
Species: Homo sapiens
Compartment: plasma membrane
Identifier: R-HSA-8851839
Species: Homo sapiens
Compartment: plasma membrane

RNA Sequence (2 results from a total of 10)

Identifier: R-HSA-9708205
Species: Homo sapiens
Compartment: cytosol
Primary external reference: RNAcentral: tRNA Met CAT: RNAcentral:URS0000145C5E_9606
Identifier: R-HSA-9708360
Species: Homo sapiens
Compartment: cytosol
Primary external reference: RNAcentral: tRNA Met CAT: RNAcentral:URS0000145C5E_9606

Reaction (2 results from a total of 355)

Identifier: R-HSA-8875374
Species: Homo sapiens
Compartment: plasma membrane
LRIG1 can bind the MET receptor in the absence of HGF-mediated MET activation and trigger MET downregulation in a CBL-independent manner (Shattuck et al. 2007). MET targeting by the therapeutic antibody SAIT301 leads to LRIG1-mediated MET degradation through the lysosomal route. LRIG1-mediated MET downregulation requires ubiquitination of LRIG1 by an unknown ubiquitin ligase and can be inhibited by the ubiqitin hydrolase USP8, which deubiquitinates LRIG1 (Oh et al. 2014, Lee et al. 2014). Ubiquitinated LRIG1 binds to HGS (Hrs), a protein involved in clathrin-mediated endocytosis, and LRIG1 and MET co-localize with the lysosomal marker LAMP1 (Oh et al. 2014).
Identifier: R-HSA-6806957
Species: Homo sapiens
Compartment: plasma membrane
Upon ligand binding, MET receptor forms homodimers. Interaction between beta chains of two MET-bound HGF heterodimers may promote dimer formation (Stamos et al. 2004, Gherardi et al. 2006). Ligand bound MET dimers can further oligomerize (Hays and Watowich 2004).

Drug (2 results from a total of 18)

Identifier: R-ALL-9735956
Compartment: cytosol
Primary external reference: Guide to Pharmacology: SU11274: 5057
Identifier: R-ALL-9625937
Compartment: extracellular region
Primary external reference: Guide to Pharmacology: methoxamine: 483

Chemical Compound (2 results from a total of 41)

Identifier: R-ALL-174390
Compartment: cytosol
Primary external reference: ChEBI: L-methionine zwitterion: 57844
Identifier: R-ALL-379705
Compartment: mitochondrial matrix
Primary external reference: ChEBI: L-methionine zwitterion: 57844

Genes and Transcripts (2 results from a total of 35)

Identifier: R-HSA-379794
Species: Homo sapiens
Compartment: cytosol
Identifier: R-HSA-379780
Species: Homo sapiens
Compartment: mitochondrial matrix

OtherEntity (2 results from a total of 11)

Identifier: R-ALL-72393
Compartment: cytosol
Identifier: R-ALL-1222500
Compartment: cytosol
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