Search results for MIF

Showing 12 results out of 12

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Species

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Species

Types

Compartments

Reaction types

Search properties

Protein (4 results from a total of 4)

MIF

Identifier: R-HSA-212594
Species: Homo sapiens
Compartment: extracellular region
Primary external reference: UniProt: MIF: P14174

MIF

Identifier: R-HSA-6803282
Species: Homo sapiens
Compartment: secretory granule lumen
Primary external reference: UniProt: MIF: P14174

MIF

Identifier: R-HSA-6803289
Species: Homo sapiens
Compartment: ficolin-1-rich granule lumen
Primary external reference: UniProt: MIF: P14174

AMH

Identifier: R-HSA-8858256
Species: Homo sapiens
Compartment: extracellular region
Primary external reference: UniProt: AMH: P03971

DNA Sequence (2 results from a total of 2)

Identifier: R-HSA-8950444
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: ENSEMBL: MIF: ENSG00000240972
Identifier: R-HSA-8960626
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: ENSEMBL: ENSG00000104899

Complex (2 results from a total of 2)

Identifier: R-HSA-5676088
Species: Homo sapiens
Compartment: extracellular region
Identifier: R-HSA-5676093
Species: Homo sapiens
Compartment: plasma membrane

Reaction (2 results from a total of 2)

Identifier: R-HSA-5676133
Species: Homo sapiens
Compartment: extracellular region, plasma membrane
Macrophage migration inhibitory factor (MIF), one of the first cytokines to be described (George & Vaughan 1962), is an important regulator of innate and adaptive immunity. MIF is an upstream activator of monocytes/macrophages, centrally involved in the pathogenesis of septic shock, arthritis, and other inflammatory conditions (Nishihira 2000, Sanchez-NiƱo et al. 2013). High-expression Mif alleles are linked to severe rheumatoid arthritis (Morand & Leech 2005). MIF promotes monocyte/macrophage activation and it is required for the optimal expression of TNF-alpha, IL-1, and PGE2 (Calandra & Bucala 1997). MIF-treated macrophages are more phagocytic and better able to destroy intracellular pathogens, such as Leishmania (Rosado & Rodriguez-Sosa 2011). Active MIF is a 37.5 kDa homotrimer.

MIF can bind to CD74 (Leng et al. 2003) and the chemokine receptors CXCR2 and CXCR4 (Bernhagen et al. 2007). Leukocyte recruitment by MIF is mediated by interaction with CXCR2 and CXCR4 (Bernhagen et al. 2007). MIF interaction with CD74 mediates its proproliferative and antiproliferative effects, regulation of B-cell and tumor cell survival, fibrosis and angiogenesis (Starlets et al. 2006). MIF can suppress the immunosuppressive effects of glucocorticoids, inducing a sustained pattern of ERK-1/2 MAP kinase activation (Bach et al. 2009).

MIF is endocytosed to bind the cytosolic protein JAB1 (Schwartz et al. 2012), negatively regulating JAB1-controlled pathways (Kleemann et al. 2000). MIF inhibits JAB1-induced JNK activity, AP-1 activity and JAB1-dependent cell-cycle regulation by stabilizing p27Kip1 protein (Nguyen et al. 2003). Consequently, MIF blocks JAB1-mediated rescue of fibroblasts from growth arrest (Kleemann et al. 2000).
Identifier: R-HSA-8950732
Species: Homo sapiens
Compartment: secretory granule lumen, nucleoplasm
Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005). Among the up-regulated proteins is :Macrophage migration inhibitory factor(MIF).

Interactor (1 results from a total of 1)

Identifier: A9UHW6-2
Species: Homo sapiens
Primary external reference: UniProt: A9UHW6-2

Pathway (1 results from a total of 1)

Identifier: R-HSA-8950505
Species: Homo sapiens
Compartment: nucleoplasm
Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005). The identified upregulated proteins are: BOLA2, PSME2, MTAP, CA1, GSTA2, RALA, CNN2, CFL1, TCP1, HNRNPDL, MIF, AIP, SOD1, PPIA and PDCD4.
And the identified downregulated proteins are:
ANXA2, RPLP0, CAPZA1, SOD2, SNRPA1, LMNB1, LCP1, HSPA9, SERPINB2, HNRNPF, TALDO1, PAK2, TCP1, HNRNPA2B1, MSN, PITPNA, ARF1, SOD2, ANXA2, CDC42, RAP1B and GSTO1.
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