Search results for MMP3

Showing 20 results out of 56

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Species

Types

Compartments

Reaction types

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Protein (6 results from a total of 6)

Identifier: R-HSA-8943665
Species: Homo sapiens
Compartment: extracellular region
Primary external reference: UniProt: P08254
Identifier: R-HSA-1604735
Species: Homo sapiens
Compartment: extracellular region
Primary external reference: UniProt: MMP3: P08254
Identifier: R-HSA-1430778
Species: Homo sapiens
Compartment: extracellular region
Primary external reference: UniProt: MMP3: P08254
Identifier: R-HSA-1604687
Species: Homo sapiens
Compartment: extracellular region
Primary external reference: UniProt: P08254
Identifier: R-HSA-1604705
Species: Homo sapiens
Compartment: extracellular region
Primary external reference: UniProt: P08254
Identifier: R-HSA-1604707
Species: Homo sapiens
Compartment: extracellular region
Primary external reference: UniProt: P08254

DNA Sequence (1 results from a total of 1)

Identifier: R-HSA-8948372
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: ENSEMBL: ENSG00000149968

Reaction (6 results from a total of 42)

Identifier: R-HSA-1592362
Species: Homo sapiens
Compartment: extracellular region
MMP3 activates MMP7 by cleavage of Glu94-Tyr95 (Imai et al. 1997).
Identifier: R-HSA-1604752
Species: Homo sapiens
Compartment: extracellular region
MMP3 initially cleaves proMMP13 at Gly76-Leu77 followed by autoprocessing at Glu103-Tyr104 (Knauper et al. 1996).
Identifier: R-HSA-1604731
Species: Homo sapiens
Compartment: extracellular region
After the initial cleavage of the N-terminus, MMP3 undergoes autocatalysis and cleavage of the His99-Phe100 bond (Nagase et al. 1990, 1991). Residue numbering given here is based on the UniProt canonical sequence.
Identifier: R-HSA-2179413
Species: Homo sapiens
Compartment: plasma membrane, extracellular region
Gastrin activated PKC pathway leads to the induction of matrix metalloproteinase 3 (MMP3) synthesis (Reuben et al. 2002). The cleavage and autocatalysis steps to obtain the fully activated form of MMP3 have been omitted here.
Identifier: R-HSA-2179402
Species: Homo sapiens
Compartment: extracellular region
Gastrin can induce cleavage of pro-HBEGF via MMP3, releasing mature HBEGF. This event is based on evidence from mouse experiments (Suzuki et al. 1997).
Identifier: R-HSA-2533970
Species: Homo sapiens
Compartment: extracellular region
Nidogen-1 (entactin) is a member of the nidogen family of basement membrane glycoproteins. It interacts with several other components of basement membranes, notably it connects the collagen and laminin networks to each other (Yurchenko & Patton 2009). MMPs 3, 7 (Mayer et al. 1993), 1, 9, (Sires et al. 1993), 12 (Gronski et al. 1997), 14, 15 (d'Ortho et al. 1997), 19 (Stracke et al. 2000) and leukocyte elastase (Mayer et al. 1993) can all degrade Nidogen-1.

Set (6 results from a total of 6)

Identifier: R-HSA-2533973
Species: Homo sapiens
Compartment: extracellular region
Identifier: R-HSA-2534228
Species: Homo sapiens
Compartment: extracellular region
Identifier: R-HSA-2514830
Species: Homo sapiens
Compartment: extracellular region
Identifier: R-HSA-2534177
Species: Homo sapiens
Compartment: extracellular region
Identifier: R-HSA-2534258
Species: Homo sapiens
Compartment: extracellular region
Identifier: R-HSA-2484887
Species: Homo sapiens
Compartment: extracellular region

Pathway (1 results from a total of 1)

Identifier: R-HSA-2179392
Species: Homo sapiens
Gastrin, through the action of diacylglycerol produced from downstream G alpha (q) events, transactivates EGFR via a PKC-mediated pathway by activation of MMP3 (Matrix Metalloproteinase 3) which allows formation of mature HBEGF (heparin-binding epidermal growth factor) by cleaving pro-HBEGF. Mature HBEGF is then free to bind the EGFR, resulting in EGFR activation (Dufresne et al. 2006, Liebmann 2011).
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