Search results for MTMR1

Showing 17 results out of 20

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Species

Types

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Reaction types

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Protein (4 results from a total of 4)

Identifier: R-HSA-1604647
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: MTMR1: Q13613
Identifier: R-HSA-1604632
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: MTMR14: Q8NCE2
Identifier: R-HSA-6810028
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: MTMR10: Q9NXD2
Identifier: R-HSA-6809657
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: MTMR12: Q9C0I1

Set (2 results from a total of 2)

Identifier: R-HSA-1806223
Species: Homo sapiens
Compartment: cytosol
Identifier: R-HSA-5682410
Species: Homo sapiens
Compartment: cytosol

Complex (4 results from a total of 4)

Identifier: R-HSA-6810024
Species: Homo sapiens
Compartment: cytosol
Identifier: R-NUL-6810029
Species: Mus musculus, Homo sapiens
Compartment: cytosol
Identifier: R-HSA-6809705
Species: Homo sapiens
Compartment: cytosol
Identifier: R-HSA-6809679
Species: Homo sapiens
Compartment: cytosol

Reaction (7 results from a total of 10)

Identifier: R-HSA-5679206
Species: Homo sapiens
Compartment: cytosol, endoplasmic reticulum membrane
MTMR14 (Jumpy) and MTMR3 are PI3P phosphatases that negatively regulate autophagosome formation by dephosphorylating PI3P on phagophores and autophagosomes (Vergne et al. 2009, Taguchi-Atarashi et al. 2010, Vergne & Deretic 2010).
Identifier: R-HSA-6810030
Species: Homo sapiens
Compartment: cytosol
Based on a high throughput study of human interactome in HeLa cells, MTMR2 forms a complex with MTMR10, an enzymatically inactive myotubularin family member. The function of this complex has not been examined (Hein et al. 2015).
Identifier: R-NUL-6810026
Species: Homo sapiens, Mus musculus
Compartment: cytosol
Based on a high throughput study of human interactome in HeLa cells stably expressing tagged mouse Mtmr2 (97% identical to human MTMR2) under the control of mouse Mtmr2 promoter, Mtmr2 forms a complex with endogenous human MTMR10 (Hein et al. 2015).
Identifier: R-HSA-6809707
Species: Homo sapiens
Compartment: cytosol
MTMR2 forms a complex with MTMR12, an enzymatically inactive myotubularin family member. The consequences of this interaction on enzymatic activity and localization of MTMR2 have not been examined (Nandurkar et al. 2003).
Identifier: R-HSA-6809680
Species: Homo sapiens
Compartment: cytosol
MTM1 forms a complex with MTMR12 (3 PAP), an enzymatically inactive myotubularin family member. MTMR12 promotes MTM1 recruitment to cytosolic vesicular structures, presumably early or late endosomes. Complex formation stabilizes both MTM1 and MTMR12 proteins (Caldwell et al. 1991, Nandurkar et al. 2003, Gupta et al. 2013).
Identifier: R-HSA-6809720
Species: Homo sapiens
Compartment: early endosome membrane, cytosol
Binding of MTMR12 to MTM1 enhances phosphatidylinositol-3-phosphatase activity of MTM1 at cytosolic vesicular structures, presumably early or late endosomes (Caldwell et al. 1991, Nandurkar et al. 2003, Gupta et al. 2013).
Identifier: R-HSA-1676203
Species: Homo sapiens
Compartment: plasma membrane, cytosol
At the plasma membrane, synaptojanin-1 aka Synaptic inositol-1,4,5-trisphosphate 5-phosphatase 1 (SYNJ1) (Guo et al. 1999), -2 (SYNJ2) and some myotubularins (MTMs) dephosphorylate phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) to phosphatidylinositol 5-phosphate (PI5P). The MTMs involved are: myotubularin (MTM1) (Cao et al. 2007, Tronchere et al. 2004, Schaletzky et al. 2003, Laporte et al. 2002) and myotubularin-related proteins 1 (MTMR1) (Tronchere et al. 2004), 3 (MTMR3) (Walker et al. 2001, Lorenzo et al. 2005), 6 (MTMR6) (Schaletzky et al. 2003, Choudhury et al. 2006), and 14 (MTMR14) (Tosch et al. 2006).
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