Search results for MYO1C

Showing 9 results out of 9

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Species

Types

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Protein (2 results from a total of 2)

Identifier: R-HSA-1449619
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: MYO1C: O00159
Identifier: R-HSA-5250648
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: UniProt: MYO1C: O00159-3

Reaction (2 results from a total of 2)

Identifier: R-HSA-2316349
Species: Homo sapiens
Compartment: cytoplasmic vesicle membrane, cytosol
As inferred from mouse, insulin causes phosphorylation and inactivation of the Ral GTPase activating complex RGC, causing RALA:GTP to accumulate and associate with the unconventional myosin MYO1C. MYO1C, with calmodulin as a light chain, motors across cortical actin and interacts with the exocyst complex to tether vesicles at the plasma membrane (Chen et al. 2007).
Identifier: R-HSA-5250947
Species: Homo sapiens
Compartment: nucleoplasm
Active rRNA genes are bound by the B‑WICH multiprotein complex (Cavellan et al. 2006, Percipalle et al. 2006). B-WICH binds the promoter region of the gene (Percipalle et al. 2006, Sarshad et al. 2013). The MYO1C component of the B-WICH complex binds chromatin and interacts with SMARCA5. Binding causes 200 bp of chromatin at the promoter to adopt a more open configuration and contributes to epigenetic modifications compatible with transcription activation (Vintermist et al. 2011, Sarshad et al. 2013). At the rRNA gene promoter the SMARCA5-MYOIC interaction is excluded when MYOIC interacts with actin in complex with RNA polymerase I (Sarshad et al. 2013). Binding of MYOIC to chromatin is regulated by GSK3beta-dependent phosphorylation that targets the MYOIC chromatin binding domain (Sarshad et al. 2014). Binding of MYOIC to the RNA polymerase I is partly mediated via phosphorylated TIF1A (Philimonenko et al. 2004). Binding of B‑WICH to rRNA genes requires MYOIC to be recruited to active rRNA genes and this mechanism appears to be a requirement to activate and maintain transcription by RNA polymerase I (Percipalle et al. 2006, Sarshad et al. 2013, Sarshad et al. 2014, reviewed in Sarshad and Percipalle 2014).

Interactor (1 results from a total of 1)

Identifier: Q12965
Species: Homo sapiens
Primary external reference: UniProt: Q12965

Complex (2 results from a total of 2)

Identifier: R-HSA-5250916
Species: Homo sapiens
Compartment: nucleoplasm
Identifier: R-HSA-2316345
Species: Homo sapiens
Compartment: cytosol

Pathway (1 results from a total of 1)

Identifier: R-HSA-5250924
Species: Homo sapiens
Compartment: nucleoplasm
The B-WICH complex is a large 3 Mdalton complex containing SMARCA5 (SNF2H), BAZ1B (WSTF), ERCC6 (CSB), MYO1C (Nuclear myosin 1c), SF3B1, DEK, MYBBP1A, and DDX21 (Cavellan et al. 2006, Percipalle et al. 2006, Vintermist et al. 2001, Sarshad et al. 2013, Shen et al. 2013, reviewed in Percipalle and Farrants 2006). B-WICH is found at active rRNA genes as well as at 5S rRNA and 7SL RNA genes. B-WICH appears to remodel chromatin and recruit histone acetyltransferases that modify histones to transcriptionally active states.

Icon (1 results from a total of 1)

Species: Homo sapiens
Curator: Bruce May
Designer: Cristoffer Sevilla
MYO1C icon
Unconventional myosin-Ic
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