Search results for NCK2

Showing 15 results out of 22

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Species

Types

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Reaction types

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Protein (1 results from a total of 1)

Identifier: R-HSA-204885
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: NCK2: O43639

Reaction (4 results from a total of 9)

Identifier: R-HSA-8985812
Species: Homo sapiens
Compartment: plasma membrane, cytosol
Based on mouse experiments, SLIT1-activated ROBO receptors ROBO1 and/or ROBO2 bind to NCK2. The interaction involves three SH3 domains of NCK2 and the PxxP-rich region between CC2 and CC3 motifs in the cytoplasmic domain of ROBO. While NCK1 can also associate with ROBO receptors, only NCK2 is implicated in SLIT1-induced cortical dendrite branching (Round and Sun 2011).
Identifier: R-HSA-8985799
Species: Homo sapiens
Compartment: plasma membrane
Based on mouse experiments, SLIT1 binds to ROBO1 and/or ROBO2 to stimulate cortical dendrite branching (Round and Sun 2011). SLIT1-mediated activation of ROBO1 and/or ROBO2 may also be involved in regulation of midline crossing in the spinal cord (Mambetisaeva et al. 2015). SLIT1 is expressed by new neurons in the adult brain which migrate from the subventricular zone to the olfactory bulb through the rostral migratory stream. Astrocytes in the rostral migratory stream express ROBO receptors, mostly ROBO2, but also ROBO1 and ROBO3. These ROBO-expressing astrocytes are repelled by SLIT1-expressing young migrating neurons, which results in the formation and maintenance of the astrocytic tunnels. Astrocytic tunnels allow rapid directional migration of new neurons in the adult brain (Kaneko et al. 2010). Signaling through SLIT1-ROBO2 is implicated in regulation of peripheral nerve regeneration (Zhang et al. 2010).
Identifier: R-HSA-3928639
Species: Homo sapiens
Compartment: cytosol, plasma membrane
Unlike EPH receptors, ephrinBs (EFNBs) do not possess intrinsic catalytic activity and thus rely on the recruitment of signaling molecules to signal. Phosphorylated ephrinB (p-EFNB) provides docking site for the SH2/SH3 domain-containing adapter protein cytoplasmic protein NCK2 (NCK2 aka GRB4) (Cowan & Henkemeyer 2001). GRB4 is able to bind to phosphotyrosines in EFNBs through their SH2 domains and 'PxxP' motifs through their SH3 domains. It has been postulated that GRB4 acts as a bridge between EFNBs and G protein-coupled receptor kinase interacting protein (GIT) 1 and Rac at synapses (Segura et al. 2007).
Identifier: R-HSA-428515
Species: Homo sapiens
Compartment: cytosol, plasma membrane
Upon SLIT-mediated ROBO stimulation, SOS1 or SOS2 is recruited into the multiprotein complex consisting of SLIT2, ROBO1 and the SH3-SH2 protein NCK1 or NCK2 (orthologues of Drosophila Dock). NCK bridges the physical association between ROBO and SOS. This interaction was demonstrated in both Drosophila and human cells (Hu et al. 1995, Fritz et al. 2000, Yang and Bashaw 2006).

Interactor (1 results from a total of 1)

Identifier: E7ERP6
Species: Homo sapiens
Primary external reference: UniProt: E7ERP6

Set (2 results from a total of 2)

Identifier: R-HSA-381949
Species: Homo sapiens
Compartment: cytosol
Identifier: R-HSA-8985807
Species: Homo sapiens
Compartment: plasma membrane

Complex (4 results from a total of 6)

Identifier: R-HSA-8985808
Species: Homo sapiens
Compartment: plasma membrane
Identifier: R-HSA-5218798
Species: Homo sapiens
Compartment: plasma membrane
Identifier: R-HSA-5218786
Species: Homo sapiens
Compartment: plasma membrane
Identifier: R-HSA-5218795
Species: Homo sapiens
Compartment: plasma membrane

Pathway (2 results from a total of 2)

Identifier: R-HSA-8985801
Species: Homo sapiens
Besides being involved in axon repulsion during neuronal system development, SLIT-ROBO signaling is also involved in dendrite branching. Based on studies in mice, SLIT1 triggers cortical dendrite branching by activating receptors ROBO1 and/or ROBO2. ROBO effector NCK2 is needed for SLIT1-mediated dendrite branching (Round and Sun 2011).
Identifier: R-HSA-428540
Species: Homo sapiens
A low level of RAC1 activity is essential to maintain axon outgrowth. ROBO activation recruits SOS, a dual specificity GEF, to the plasma membrane via Dock homolog NCK (NCK1 or NCK2) to activate RAC1 during midline repulsion.

Icon (1 results from a total of 1)

NCK

Species: Homo sapiens
Representation of Cytoplasmic protein NCK 1 or 2
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