Search results for NEU2

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Species

Types

Compartments

Reaction types

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Protein (1 results from a total of 1)

NEU2

Identifier: R-HSA-1605759
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: NEU2: Q9Y3R4

Reaction (3 results from a total of 3)

NEU2 hydrolyzes Neu5Ac from glycoconjugates

Identifier: R-HSA-4085029
Species: Homo sapiens
Compartment: cytosol
Sialidases 1-4 (NEU1-4, neuraminidases, receptor-destroying enzymes, RDEs) hydrolyze sialic acids (N-acetylneuraminic acid, Neu5Ac) to produce asialo compounds, a step in the degradation process of glycoproteins and gangliosides and are expressed in a variety of cellular locations. NEU2 (cytosolic sialidase) hydrolyzes Neu5Ac from glycoconjugates with alpha2,3-, alpha2,6- or alpha2,8-linked terminal sialated residues in the cytosol (Monti et al. 1999, Chavas et al. 2005).

NEU2 cleaves GM3 to form LacCer (cytosol)

Identifier: R-HSA-1605723
Species: Homo sapiens
Compartment: cytosol
Sialidase-2 (NEU2) hydrolyses Neu5Ac from GM3 in the cytosol (Monti et al. 1999).

Plasma membrane glycoconjugates translocate to the cytosol

Identifier: R-HSA-4088205
Species: Homo sapiens
Compartment: cytosol, plasma membrane
Glycoconjugates have to translocate to the cytosol for degradation by cytosol-specific sialidase 2 (NEU2). The mechanism of translocation is unknown but could simply be by diffusion (Li & Chen 2012).
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