Search results for NEU3

Showing 4 results out of 4

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Species

Types

Compartments

Reaction types

Search properties

Protein (1 results from a total of 1)

Identifier: R-HSA-1605644
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: NEU3: Q9UQ49

Set (1 results from a total of 1)

Identifier: R-ALL-4088088
Compartment: plasma membrane

Reaction (2 results from a total of 2)

Identifier: R-HSA-4084994
Species: Homo sapiens
Compartment: cytosol, plasma membrane
Sialidases 1-4 (NEU1-4, neuraminidases, receptor-destroying enzymes, RDEs) hydrolyze sialic acids (N-acetylneuraminic acid, Neu5Ac) to produce asialo compounds, a step in the degradation process of glycoproteins and gangliosides and are expressed in a variety of cellular locations. NEU3 localizes to the plasma membrane and hydrolyses Neu5Ac especially from gangliosides with alpha2,3- or alpha2,8-linkages present in the lipid bilayer (Wada et al. 1999, Monti et al. 2000). By regulating the composition of the lipid bilayer, NEU3 has been identified as an important regulator of trans-membrane signaling (Miyagi et al. 2008).
Identifier: R-HSA-1605768
Species: Homo sapiens
Compartment: cytosol, plasma membrane
Sialidase-3 (NEU3) cleaves Neu5Ac from GM3 in the plasma membrane. NEU3 is thought to play a role in modulating the ganglioside content of the lipid bilayer (Monti et al. 2000).
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