Search results for NR5A1

Showing 17 results out of 20

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Protein (5 results from a total of 5)

Identifier: R-HSA-452955
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: UniProt: NR5A1: Q13285
Identifier: R-HSA-4546383
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: UniProt: NR5A1: Q13285
Identifier: R-HSA-4546382
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: UniProt: Q13285
Identifier: R-HSA-4546380
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: UniProt: P63165
Identifier: R-HSA-4546379
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: UniProt: P63165

Reaction (7 results from a total of 10)

Identifier: R-HSA-4546385
Species: Homo sapiens
Compartment: nucleoplasm
PIAS1,3 SUMOylate NR5A1 (Steroidogenic factor 1, SF1, SF-1) at lysine-119 and lysine-194 with SUMO2 (Chen et al. 2004, Komatsu et al. 2004, Suda et al. 2011). SUMOylation reduces synergistic activation of SOX9 by NR5A1.
Identifier: R-HSA-4546386
Species: Homo sapiens
Compartment: nucleoplasm
PIAS1,3 SUMOylate NR5A1 (Steroidogenic factor 1, SF1, SF-1) at lysine-119 and lysine-194 with SUMO1 (Chen et al. 2004, Komatsu et al. 2004, Suda et al. 2011). SUMOylation reduces the synergistic activation of SOX9 by NR5A1.
Identifier: R-HSA-9692135
Species: Homo sapiens
Compartment: nucleoplasm
SOX9, NR5A1 (SF1), and GATA4 bind the promoter of the AMH gene (De Santa Barbara et al. 1998 and inferred from mouse homologs). SOX9 and NR5A1 interact directly (De Santa Barbara et al. 1998).
Identifier: R-HSA-9690414
Species: Homo sapiens
Compartment: nucleoplasm
SRY and NR5A1 (SF1) bind several sites in the TES enhancer upstream of the SOX9 coding region (Knower et al. 2011) and the eALDI enhancer upstream of TES (Croft et al. 2018, and inferred from mouse homologs). SRY weakly enhances SOX9 expression only when NR5A1 is also bound to the TES enhancer (inferred from mouse homologs). SRY bound to eALDI more strongly activates SOX9 (Croft et al. 2018).
Identifier: R-HSA-9692250
Species: Homo sapiens
Compartment: nucleoplasm
The transcription factors WT1 (Shimamura et al. 1997, Hossain and Saunders 2001, Miyamoto et al. 2008, also inferred from mouse homologs), NR5A1 (also called SF1) (De Santa Barbara et al. 2001), GATA4:ZFPM2 (also called GATA4:FOG2) (Miyamoto et al. 2008, also inferred from mouse homologs) bind the promoter of the SRY gene and activate transcription of SRY. SRY is a mammal-specific gene located on the Y chromosome that is responsible for male sex determination.
Identifier: R-HSA-9690395
Species: Homo sapiens
Compartment: nucleoplasm
SOX9 together with NR5A1 (SF1) binds the TES enhancer and other enhancers upstream of the SOX coding region (Croft et al. 2018 and inferred from mouse homologs) and thereby activates its own expression. As SRY expression decreases during testis differentiation, SOX9 and, later, DMRT1 become responsible for maintaining expression of SOX9.
Identifier: R-HSA-9690404
Species: Homo sapiens
Compartment: nucleoplasm
Subsequent to SRY expression in the gonadal ridge, the SOX9 gene is transcribed to yield mRNA and the mRNA is translated to yield SOX9 protein (Knower et al. 2011, Croft et al. 2018). SRY and NR5A1 (SF1) bound at the TES enhancer (Knower et al. 2011) and the eALDI enhancer (upstream of the TES enhancer, Croft et al. 2018) of the SOX9 gene initially activate transcription of SOX9 (Knower et al. 2011, Croft et al. 2018, and inferred from mouse homologs). Later, SOX9 and NR5A1 activate the TES enhancer, providing a mechanism for autoregulation (Knower et al. 2011). DMRT1, itself directly activated by SOX9, also directly activates SOX9 (inferred from mouse homologs). FGF9 acting through FGFR2 (inferred from mouse homologs) and Prostaglandin D2 (Malki et al. 2005), the product of PTGDS, activate SOX9 through less well characterized mechanisms.

Complex (4 results from a total of 4)

Identifier: R-HSA-4546374
Species: Homo sapiens
Compartment: nucleoplasm
Identifier: R-HSA-9690386
Species: Homo sapiens
Compartment: nucleoplasm
Identifier: R-HSA-9692117
Species: Homo sapiens
Compartment: nucleoplasm
Identifier: R-HSA-9692256
Species: Homo sapiens
Compartment: nucleoplasm

Pathway (1 results from a total of 1)

Identifier: R-HSA-9690406
Species: Homo sapiens
In humans, primordial germ cells (PGCs) are specified about 2 weeks after fertilization, a time before gastrulation (reviewed in Svingen and Koopman 2013, Mäkelä et al. 2019). PGCs are initially located extraembryonically and then migrate to colonize the gonadal ridges (genital ridges) of the embryo during the fifth week after fertilization. At this time, either ovaries and testes can originate from the gonadal ridges. That is, the cells of the gonadal ridges are initially bipotential and remain bipotential until about 42 days after conception, when transient expression of the SRY gene located on the Y chromosome in male embryos is initiated in some somatic cells of the gonadal primordium (reviewed in Sekido and Lovell-Badge 2013, Barrionuevo et al. 2013, Svingen et al. 2013, Mäkelä et al. 2019).
The transcription factors WT1, GATA4, ZFPM2 (FOG2), and the nuclear receptor NR5A1 (SF1) activate transcription of SRY (Shimamura et al. 1997, Hossain and Saunders 2001, De Santa Barbara et al. 2001, Miyamoto et al. 2008, and inferred from mouse homologs). SRY and NR5A1 then activate transcription of SOX9, one of the master regulators of testis development and maintenance (Knower et al. 2011, Croft et al. 2018, inferred from mouse homologs, reviewed in Gonen and Lovell-Badge 2019). Regulation of genes by SRY and then, when expression of SRY decreases, by SOX9 causes the specification of Sertoli cells that further organize formation of the testis by encasing the primordial germ cells in protocords, which then form fully developed testis cords.
SOX9 directly activates its own promoter to maintain SOX9 expression through development and into adulthood (Croft et al. 2018, and inferred from mouse homologs). SOX9 and GATA4 directly activate DMRT1 (inferred from mouse homologs), which maintains testis specification by maintaining expression of SOX9 and other testis-related genes. DMRT1 also acts to suppress ovarian specification by binding and repressing FOXL2 and WNT4 genes (inferred from mouse homologs). SOX9 directly activates FGF9 (inferred from mouse homologs), which acts via FGFR2 to maintain SOX9 expression, and PTGDS (inferred from mouse homologs), which converts Prostaglandin H2 to Prostaglandin D2, a critical hormone-like lipid that recruits supporting cells to Sertoli cells and acts indirectly to maintain SOX9 expression. SOX9, NR5A1, and GATA4 directly activate AMH (De Santa Barbara et al. 1998, and inferred from mouse homologs), an extracellular signaling molecule which causes regression of the Muellerian duct of the female reproductive system. SOX9 also directly activates many other genes, including DHH (Rahmoun et al. 2017, and inferred from mouse homologs), an intercellular signaling molecule required for testis formation.
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