Search results for NUP153

Showing 4 results out of 4

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Species

Types

Compartments

Search properties

Protein (1 results from a total of 1)

Identifier: R-HSA-157695
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: UniProt: NUP153: P49790

Reaction (2 results from a total of 2)

Identifier: R-HSA-5661474
Species: Homo sapiens
Compartment: cytosol, nuclear envelope
The nuclear pore complex (NPC) trafficks cargo across the nuclear membrane. Nucleoprotein TPR functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. The complex glucokinase (GCK1) and glucokinase regulatory protein (GKRP) can be translocated to the nucleus via the NPC. Defects in TPR may confer susceptibility towards thyroid papillary carcinona (TPC; MIM:18850), a common tumor of the thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Mutations in TPR that can confer susceptibility to TPC are L458P and M489P (Hase et al. 2001, Hase & Cordes 2003).
Identifier: R-HSA-3134914
Species: Homo sapiens
Compartment: cytosol, nuclear envelope, nucleoplasm
Phosphorylated beta-catenin migrates to the nucleus where it functions as a coactivator of IRF3-dependent transcription (Yang P et al. 2010).

Beta-catenin transport to the nucleus is thought to occur in a NLS (nuclear localization signal)- and importin-independent manner through direct interaction with the nuclear pore complex (NPC) components. This has been shown to be the case for Wnt-signaling in mammalian cells (Yokoya F et al. 1999; Koike M et al. 2004; Sharma M et al. 2012)

Complex (1 results from a total of 1)

Identifier: R-HSA-9631759
Species: Homo sapiens
Compartment: nuclear envelope
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