Search results for P00533

Showing 30 results out of 59

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Results (30 results from a total of 59)

Identifier: R-HSA-179803
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: EGFR: P00533
Identifier: R-HSA-179868
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: EGFR: P00533
Identifier: R-HSA-8864019
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: EGFR: P00533
Identifier: R-HSA-180287
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: EGFR: P00533
Identifier: R-HSA-1228016
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: EGFR: P00533
Identifier: R-HSA-1996314
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: P00533
Identifier: R-HSA-1996315
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: P00533
Identifier: R-HSA-1177531
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: P00533
Identifier: R-HSA-1228025
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: P00533
Identifier: R-HSA-1996306
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: P00533
Identifier: R-HSA-1177532
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: P00533
Identifier: R-HSA-1228031
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: P00533
Identifier: R-HSA-1228034
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: P00533
Identifier: R-HSA-1996330
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: P00533
Identifier: R-HSA-1177542
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: P00533
L861Q, a substitution of leucine 861 with glutamine, is a documented EGFR mutation in the non-small-cell lung cancer (NSCLC). Leu861, encoded by exon 21, localizes to the N-terminal portion of the activation loop (A loop) of the kinase domain of EGFR and together with Leu858 participates in hydrophobic interactions that keep the kinase in the inactive conformation (Zhang et al. 2006). Replacement of Leu861 with glutamine is expected to destabilize the inactive conformation of EGFR and result in constitutive catalytic activity (Zhang et al. 2006). NSCLCs harboring L861Q mutation in EGFR are responsive to small EGFR-specific tyrosine kinase inhibitors from the 4-anilinoquinazoline group gefitinib (Lynch et al. 2004) and are expected to be responsive to the related drug, erlotinib.
Identifier: R-HSA-1996327
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: P00533
Identifier: R-HSA-1228015
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: P00533
Identifier: R-HSA-1228012
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: P00533
Identifier: R-HSA-1996321
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: P00533
Identifier: R-HSA-1228010
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: P00533
Identifier: R-HSA-1181211
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: P00533
Identifier: R-HSA-1169418
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: P00533
Identifier: R-HSA-1173212
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: P00533
L858R, a substitution of leucine 858 with arginine, accounts for ~40% of EGFR mutations in the non-small-cell lung cancer. L858R, encoded by exon 21, localizes to the N-terminal portion of the activation loop (A loop) of the kinase domain of EGFR. By locking the EGFR in its active conformation, L858R mutation results in constitutive catalytic activity of EGFR which is ~50-fold higher than the activity of the wild-type enzyme (Yun et al. 2007). The L858R EGFR mutant is inhibited by binding of small EGFR-specific tyrosine kinase inhibitors from the 4-anilinoquinazoline group, erlotinib and gefitinib, as well as the pyrrolopyrimidine compound AEE788. Gefitinib is ~100-fold more potent against the L858R mutant than against the wild-type EGFR kinase (Yun et al. 2007). Erlotinib (Pao et al. 2004) and AEE788 (Yun et al. 2007) are also more efficient in inhibiting the L858R mutant than the wild-type EGFR.
Identifier: R-HSA-1996317
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: P00533
Identifier: R-HSA-1996326
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: P00533
Identifier: R-HSA-1996325
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: P00533
Identifier: R-HSA-1996322
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: P00533
Identifier: R-HSA-1181399
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: P00533
Secondary mutation T790M in EGFR E746_A750del mutant confers TKI resistance and results in cancer progression in patients initially responsive to TKI therapy (Balak et al. 2006).
Identifier: R-HSA-1181386
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: P00533
Secondary mutation T790M in EGFR L858R mutant confers TKI resistance and results in cancer progression in patients initially responsive to TKI therapy (Balak et al. 2006).
Identifier: R-HSA-1177528
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: P00533