Search results for P02748

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Identifier: R-HSA-173717
Species: Homo sapiens
Compartment: extracellular region
Primary external reference: UniProt: C9: P02748
Species: Homo sapiens
The membrane attack complex (MAC) or terminal complement complex (TCC) is a structure typically formed on the surface of pathogen cell membranes as a result of the activation of the host's complement system, and as such is one of the effector proteins of the immune system. MAC forms transmembrane channels that disrupt the cell membrane of target cells, leading to cell lysis and death. Active MAC is composed of the subunits C5b, C6, C7, C8 and several C9 molecules

C9

Species: Homo sapiens
Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C9 is the pore-forming subunit of the MAC
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