Search results for P29353
Showing 23 results out of 23
Results (23 results from a total of 23)
Identifier: R-HSA-1169488
Species:
Homo sapiens
Compartment:
cytosol
Primary external reference: UniProt: SHC1:
P29353
Identifier: R-HSA-1169451
Species:
Homo sapiens
Compartment:
cytosol
Primary external reference: UniProt: SHC1:
P29353
Identifier: R-HSA-74680
Species:
Homo sapiens
Compartment:
cytosol
Primary external reference: UniProt: SHC1:
P29353
Identifier: R-HSA-2404166
Species:
Homo sapiens
Compartment:
plasma membrane
Primary external reference: UniProt: SHC1:
P29353
Identifier: R-HSA-2404179
Species:
Homo sapiens
Compartment:
plasma membrane
Primary external reference: UniProt: SHC1:
P29353
Identifier: R-HSA-2404168
Species:
Homo sapiens
Compartment:
plasma membrane
Primary external reference: UniProt: SHC1:
P29353
Identifier: R-HSA-1433366
Species:
Homo sapiens
Compartment:
cytosol
Primary external reference: UniProt: SHC1:
P29353
Identifier: R-HSA-912321
Species:
Homo sapiens
Compartment:
cytosol
Primary external reference: UniProt: SHC1:
P29353
Identifier: R-HSA-162568
Species:
Homo sapiens
Compartment:
cytosol
Primary external reference: UniProt: SHC1:
P29353
Identifier: R-HSA-1169507
Species:
Homo sapiens
Compartment:
plasma membrane
Primary external reference: UniProt: SHC1:
P29353
Identifier: R-HSA-1169439
Species:
Homo sapiens
Compartment:
plasma membrane
Primary external reference: UniProt: SHC1:
P29353
Identifier: R-HSA-180276
Species:
Homo sapiens
Compartment:
cytosol
Primary external reference: UniProt: SHC1:
P29353
Identifier: R-HSA-74684
Species:
Homo sapiens
Compartment:
cytosol
Primary external reference: UniProt: SHC1:
P29353
Identifier: R-HSA-1433505
Species:
Homo sapiens
Compartment:
cytosol
Primary external reference: UniProt: SHC1:
P29353
Identifier: R-HSA-8851895
Species:
Homo sapiens
Compartment:
cytosol
Primary external reference: UniProt: SHC1:
P29353
Identifier: R-HSA-1433476
Species:
Homo sapiens
Compartment:
cytosol
Primary external reference: UniProt: SHC1:
P29353
Identifier: R-HSA-8934453
Species:
Homo sapiens
Compartment:
cytosol
Primary external reference: UniProt: SHC1:
P29353
Identifier: R-HSA-2404176
Species:
Homo sapiens
Compartment:
cytosol
Primary external reference: UniProt: SHC1:
P29353
Identifier: R-HSA-8934452
Species:
Homo sapiens
Compartment:
cytosol
Primary external reference: UniProt: SHC1:
P29353
Identifier: R-HSA-9028332
Species:
Homo sapiens
Compartment:
cytosol
Primary external reference: UniProt: SHC1:
P29353
Identifier: R-HSA-452100
Species:
Homo sapiens
Compartment:
cytosol,
plasma membrane
Following IL2 stimulation of IL2R, Shc is known to be tyrosine phosphorylated (Zhu et al. 1994). The identity of the kinase is uncertain (Gesbert et al. 1998); JAK1 may be responsible but this has not been demonstrated, another candidate is Lck.
Following IL-3 treatment, Shc becomes tyrosyl phoshorylated at 3 sites, Y427 (Salcini et al. 1994), Y349 and Y350 (Gotoh et al. 1996). Y427 mediates the subsequent association with Grb2 (Salcini et al. 1994).
Numbering here refers to Uniprot P29353 where the p66 isoform has been selected as the canonical form. Literature references used here refer to the p52 isoform which lacks the first 110 residues, so Y427 is referred to as Y317 in Salcini et al. 1994, Y349 and Y350 as Y239 and Y240 in Gotoh et al. 1996.
Following IL-3 treatment, Shc becomes tyrosyl phoshorylated at 3 sites, Y427 (Salcini et al. 1994), Y349 and Y350 (Gotoh et al. 1996). Y427 mediates the subsequent association with Grb2 (Salcini et al. 1994).
Numbering here refers to Uniprot P29353 where the p66 isoform has been selected as the canonical form. Literature references used here refer to the p52 isoform which lacks the first 110 residues, so Y427 is referred to as Y317 in Salcini et al. 1994, Y349 and Y350 as Y239 and Y240 in Gotoh et al. 1996.
Identifier: R-HSA-879925
Species:
Homo sapiens
Compartment:
plasma membrane
IL-3, IL-5 and GM-CSF all induce tyrosine phosphorylation of Shc (Dorsch et al. 1994). Three sites are known to mediate specific downstream associations; tyrosine Y427 (Salcini et al. 1994) mediates the subsequent association of Shc with Grb2 (Salcini et al. 1994). The identity of the kinase is unknown. Y349 and Y350 phosphorylation is not required for Ras-MAPK signaling but are involved in IL-3-induced cell survival (Gotoh et al. 1996).
Residue numbering used here refers to Uniprot P29353 where the p66 isoform has been selected as the canonical form. Literature references given here refer to the p52 isoform which lacks the first 110 residues, so Y427 is referred to as Y317 in Salcini et al. 1994, Y349 and Y350 as Y239 and Y240 in Gotoh et al. 1996.
Residue numbering used here refers to Uniprot P29353 where the p66 isoform has been selected as the canonical form. Literature references given here refer to the p52 isoform which lacks the first 110 residues, so Y427 is referred to as Y317 in Salcini et al. 1994, Y349 and Y350 as Y239 and Y240 in Gotoh et al. 1996.
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