Search results for P29460

Showing 6 results out of 6

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Results (6 results from a total of 6)

Identifier: R-HSA-447181
Species: Homo sapiens
Compartment: extracellular region
Primary external reference: UniProt: IL12B: P29460
Identifier: R-HSA-8950126
Species: Homo sapiens
Compartment: endoplasmic reticulum lumen
Primary external reference: UniProt: P29460
Interleukin-12 subunit beta have to be in the reticuum where it suffers processing by the PDI enzyme if it is going to homodimerize or heterodimerize with other subunits as Interleukin-23 alpha subunit (PMID:15720785)
Identifier: R-HSA-8950675
Species: Homo sapiens
Compartment: late endosome lumen
Primary external reference: UniProt: P29460
Identifier: R-HSA-8950359
Species: Homo sapiens
Compartment: Golgi lumen
Primary external reference: UniProt: P29460
Identifier: R-HSA-8950760
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: P29460
Identifier: R-HSA-8951201
Regulator: IL12B
Both in mouse and in human systems, it was demonstrated that p40 homodimer [complex conformed by two P29460 proteins] and to a lesser extent also the product of its dissociation, free p40[P29460] monomer, can suppress the responsiveness to IL-12 by competitively inhibiting the IL-12 receptor binding.