Search results for P42345

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Identifier: R-HSA-165662
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: MTOR: P42345
Identifier: R-HSA-5083674
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: UniProt: MTOR: P42345
Species: Homo sapiens
Curator: Karen Rothfels
Designer: Cristoffer Sevilla
mTOR icon
Serine/threonine-protein kinase mTOR
Species: Homo sapiens
Curator: Bruce May
Designer: Cristoffer Sevilla
mTORC1 icon
mTORC1, also known as mammalian target of rapamycin complex 1 or mechanistic target of rapamycin complex 1, is a protein complex that functions as a nutrient/energy/redox sensor and controls protein synthesis. mTOR Complex 1 (mTORC1) is composed of mTOR itself, regulatory-associated protein of mTOR (Raptor), mammalian lethal with SEC13 protein 8 (MLST8), PRAS40 and DEPTOR. This complex embodies the classic functions of mTOR, namely as a nutrient/energy/redox sensor and controller of protein synthesis. The activity of this complex is regulated by rapamycin, insulin, growth factors, phosphatidic acid, certain amino acids and their derivatives (e.g., l-leucine and β-hydroxy β-methylbutyric acid), mechanical stimuli, and oxidative stress
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