Search results for PCSK2

Showing 7 results out of 7

×

Species

Types

Compartments

Reaction types

Search properties

Species

Types

Compartments

Reaction types

Search properties

Protein (1 results from a total of 1)

Identifier: R-HSA-265156
Species: Homo sapiens
Compartment: secretory granule lumen
Primary external reference: UniProt: PCSK2: P16519

Reaction (4 results from a total of 4)

Identifier: R-HSA-9023178
Species: Homo sapiens
Compartment: secretory granule lumen
PCSK2 (Prohormone Convertase 2) cleaves C-terminal to arginine-89 between the C-peptide and the A-chain (INS 90-110) (Smeekens et al. 1992, Bailyes et al. 1995, Itoh et al. 1996, Kaufmann et al. 1997 and inferred from rat Pcsk2). The reaction occurs in immature secretory granules (Orci et al. 1985).
Overall, proinsulin in proinsulin-zinc-calcium complexes is cleaved by endopeptidases PCSK1 (Prohormone Convertase 1/3) and PCSK2 (Prohormone Convertase 2). The exopeptidase CPE (Carboxypeptidase E, also called Carboxypeptidase H) removes 2 amino acids from the carboxyl termini of the resulting B chain (INS 25-56) and C-peptide (INS 57-87). In the major pathway of processing PCSK1 cleaves between the B chain and the C-peptide, CPE removes two arginine residues from the C-terminus of the B chain, PCSK2 cleaves between the C-peptide and the A chain (INS 90-110), and CPE removes an arginine residue and a lysine residue from the C-terminus of the C-peptide. Unlike the proinsulin-zinc calcium complex, the insulin-zinc-calcium complex is not soluble and forms crystals inside the secretory granules.
Identifier: R-NUL-9023180
Species: Rattus norvegicus, Homo sapiens
Compartment: secretory granule lumen
Rat Pcsk2 (Prohormone Convertase 2) cleaves C-terminal to arginine-89 between the C-peptide and the A-chain (INS 90-110) of human proinsulin (Davidson et al. 1988, Rhodes et al. 1992, Bailyes et al. 1995).
Identifier: R-HSA-9023163
Species: Homo sapiens
Compartment: secretory granule membrane
Carboxypeptidase E (CPE, also called Carboxypeptidase H) removes two arginine residues from the C-terminus of the B chain (Chen et al. 2001 and inferred from rat Cpe). The reaction occurs in immature secretory granules (Orci et al. 1985)
Overall, proinsulin in proinsulin-zinc-calcium complexes is cleaved by endopeptidases PCSK1 (Prohormone Convertase 1/3) and PCSK2 (Prohormone Convertase 2). The exopeptidase CPE (Carboxypeptidase E, also called Carboxypeptidase H) removes 2 amino acids from the carboxyl termini of the resulting B chain (INS 25-56) and C-peptide (INS 57-87). In the major pathway of processing PCSK1 cleaves between the B chain and the C-peptide, CPE removes two arginine residues from the C-terminus of the B chain, PCSK2 cleaves between the C-peptide and the A chain (INS 90-110), and CPE removes an arginine residue and a lysine residue from the C-terminus of the C-peptide. Unlike the proinsulin-zinc calcium complex, the insulin-zinc-calcium complex is not soluble and forms crystals inside the secretory granules.
Identifier: R-HSA-9023196
Species: Homo sapiens
Compartment: secretory granule lumen
PCSK1 cleaves C-terminal to arginine-56 in proinsulin to yield the B chain (plus two C-terminal arginine residues) and a peptide containing the C-peptide and the A chain ( Jackson et al. 2003, Jackson et al. 1997 and inferred from rat Pcsk1). The reaction occurs in immature secretory granules (Orci et al. 1985).
Overall, proinsulin in proinsulin-zinc-calcium complexes is cleaved by endopeptidases PCSK1 (Prohormone Convertase 1/3) and PCSK2 (Prohormone Convertase 2). The exopeptidase CPE (Carboxypeptidase E, also called Carboxypeptidase H) removes 2 amino acids from the carboxyl termini of the resulting B chain (INS 25-56) and C-peptide (INS 57-87). In the major pathway of processing PCSK1 cleaves between the B chain and the C-peptide, CPE removes two arginine residues from the C-terminus of the B chain, PCSK2 cleaves between the C-peptide and the A chain (INS 90-110), and CPE removes an arginine residue and a lysine residue from the C-terminus of the C-peptide. Unlike the proinsulin-zinc calcium complex, the insulin-zinc-calcium complex is not soluble and forms crystals inside the secretory granules.

Pathway (1 results from a total of 1)

Identifier: R-HSA-2980736
Species: Homo sapiens
Compartment: COPII-coated ER to Golgi transport vesicle, Golgi lumen, cytosol, endoplasmic reticulum lumen, endoplasmic reticulum membrane, extracellular region, nucleoplasm, plasma membrane, secretory granule lumen, secretory granule membrane
Peptide hormones are cleaved from larger precursors in the secretory system (endoplasmic reticulum, Golgi apparatus, secretory granules) of the cell. After secretion peptide hormones are modified and degraded by extracellular proteases.
Insulin processing occurs in 4 steps: formation of intramolecular disulfide bonds, formation of proinsulin-zinc-calcium complexes, proteolytic cleavage of proinsulin by PCSK1 (PC1/3) and PCSK2 to yield insulin, translocation of the granules across the cytosol to the plasma membrane.
During Synthesis, secretion, and deacetylation of Ghrelin, proghrelin is acylated by ghrelin O-acyltransferase and cleaved by PCSK1 to yield the mature acyl ghrelin and C-ghrelin. In the bloodstream acyl ghrelin is deacylated by butyrylcholinesterase and platelet-activating factor acetylhydrolase.
During Metabolism of Angiotensinogen to Angiotensin, Renin cleaves angiotensinogen to yield a decapaptide, angiotensin I (angiotensin-1, angiotensin-(1-10)). Two C-terminal amino acid residues of angiotensin I are then removed by angiotensin-converting enzyme (ACE), located on the surface of endothelial cells, to yield angiotensin II (angiotensin-2, angiotensin-(1-8)), the active peptide that causes vasoconstriction, resorption of sodium and chloride, excretion of potassium, water retention, and aldosterone secretion. More recently other, more tissue-localized pathways leading to angiotensin II and alternative derivatives of angiotensinogen have been identified and described.
Incretin synthesis, secretion, and inactivation occurs through processing of incretin precursors (preproGLP-1 and preproGIP) by PCSK1. After secretion both incretins (GLP-1 and GIP) can be inactivated by cleavage by DPP4.
Peptide hormone biosynthesis describes processing of glycoprotein hormones (those which include carbohydrate side-chains) and corticotropin.

Icon (1 results from a total of 1)

Species: Homo sapiens
Curator: Bruce May
Designer: Cristoffer Sevilla
PCSK2 icon
Neuroendocrine convertase 2
Cite Us!