Search results for PDE1B

Showing 4 results out of 4

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Species

Types

Compartments

Search properties

Protein (2 results from a total of 2)

Identifier: R-HSA-52371
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: Q01064
Can hydrolyze both cAMP and cGMP
Identifier: R-HSA-9014908
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: PDE1B: Q01064
Can hydrolyze both cAMP and cGMP

Complex (1 results from a total of 1)

Identifier: R-HSA-9014910
Species: Homo sapiens
Compartment: cytosol

Pathway (1 results from a total of 1)

Identifier: R-HSA-111957
Species: Homo sapiens
Compartment: cytosol
Human Ca2+/calmodulin-dependent phosphodiesterase PDE1 is activated by the binding of calmodulin in the presence of Ca(2+). PDE1 has three subtypes PDE1A, PDE1B and PDE1C and their role is to hydrolyze both cGMP and cAMP. Their role is to antagonize the increased concentration of the intracellular second messengers determined by the synthetic activity of the adenylate cyclase enzymes thus governing intracellular cAMP dynamics in response to changes in the cytosolic Ca2+ concentration. PDE1 are mainly cytosolic but different isoforms are expressed in different tissues.
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