Search results for PDE3B

Showing 8 results out of 8

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Species

Types

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Reaction types

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Protein (2 results from a total of 2)

Identifier: R-HSA-162348
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: Q13370
Can hydrolyze both cAMP and cGMP
Identifier: R-HSA-162419
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: PDE3B: Q13370

Pathway (2 results from a total of 2)

Identifier: R-HSA-165160
Species: Homo sapiens
AKT (PKB) is recruited to the plasma membrane by binding phosphatidylinositol (3,4,5)-trisphosphate (PIP3). AKT is then activated by phosphorylation. Activated AKT in turn phosphorylates Phosphodiesterase 3B (PDE3B) which hydrolyzes 3',5'-cyclic AMP (cAMP) (reviewed in Manning and Toker 2017).
Identifier: R-HSA-109703
Species: Homo sapiens
PKB and PDK1 are activated via membrane-bound PIP3. Activated PDK1 phosphorylates PKB, which in turn phosphorylates PDE3B. The latter hydrolyses cAMP to 5'AMP, depleting cAMP pools.

Reaction (4 results from a total of 4)

Identifier: R-HSA-9705507
Species: Homo sapiens
Compartment: cytosol
Cyclic nucleotide phosphodiesterases (PDEs) are a large family of enzymes that regulate signal transduction by the second messenger molecules cAMP and cGMP (Maurice 2005). PDEs are important as drug targets:PDE3B inhibition promotes cardiac muscle contraction, a strategy used in heart failure.
Identifier: R-HSA-162363
Species: Homo sapiens
Compartment: plasma membrane, cytosol
Based on work done in mouse with AKT1, AKT2 is predicted to phosphorylate PDE3B downstream of insulin signaling (Wijknader et al, 1998; Kitamura et al, 1999; Ahmad et al, 2000; reviewed in Degerman et al, 2011).
Identifier: R-HSA-162425
Species: Homo sapiens
Compartment: cytosol
PDE3B hydrolyzes cAMP to AMP downstream of insulin signaling to regulate energy homeostasis (Marganiello et al, 1995; Degerman et al, 1997; Degerman et al, 2011; DiPilato et al, 2015).
Identifier: R-HSA-1676048
Species: Homo sapiens
Compartment: plasma membrane, cytosol
At the plasma membrane, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunits form complexes with regulatory subunits. These complexes phosphorylate phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) to phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3) (Stephens et al. 1997). The PI(4,5)P2 3-kinase complexes involved are: PI(4,5)P2 3-kinase catalytic subunit alpha isoform (PIK3CA) bound to PI 3-kinase regulatory subunit alpha/beta/gamma (PIK3R1/2/3); beta (PIK3CB) bound to PIK3R1/2/3; delta (PIK3CD) bound to PIK3R1/2/3; and gamma (PIK3CG) bound to PI 3-kinase regulatory subunit 5 (PIK3R5) or 6 (PIK3R6).

The following lists the above proteins with their corresponding literature references: PIK3CA:PIK3R1, PIK3CA:PIK3R2, PIK3CA:PIK3R3 (Dey et al. 1998, Vanhaesebroeck et al. 1997, Meier et al. 2004); PIK3CB:PIK3R1, PIK3CB:PIK3R2, PIK3CB:PIK3R3 (Meier et al. 2004); PIK3CD:PIK3R1, PIK3CD:PIK3R2, PIK3CD:PIK3R3 (Vanhaesebroeck et al. 1997, Meier et al. 2004); and PIK3CG:PIK3R5, PIK3CG:PIK3R6 (Voigt et al. 2006, Suire et al. 2005, Stoyanov et al. 1995).
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