Search results for PIK3C3

Showing 9 results out of 9

×

Species

Types

Compartments

Reaction types

Search properties

Species

Types

Compartments

Reaction types

Search properties

Reaction (9 results from a total of 9)

Identifier: R-HSA-6798174
Species: Homo sapiens
Compartment: phagocytic vesicle membrane, cytosol
1-phosphatidyl-1D-myo-inositol 3-phosphate (PI3P) is generated largely by the Class III PI3 kinase Phosphatidylinositol 3-kinase catalytic subunit type 3 (PIK3C3, Vps34), which is found in intracellular membrane complexes with Phosphoinositide 3-kinase regulatory subunit 4 (PIK3R4, Vps150), necessary for catalytic activity, localization and stability (Florey & Overholtzer 2012, Raiborg et al. 2013). These core subunits are frequently associated with other partners such as Rab5, Beclin-1 and UVRAG.

PI3P strongly upregulates phagosomal NADPH oxidase activity (Hawkins et al. 2010). This effect is mediated by PI3P binding to the PX domain of Neutrophil cytosol factor 4 (NCF4, p40phox), a component of the NOX2 complex. PI3P controls ROS production by regulating the presence of NCF4 and NCF2 (p67phox) at the phagosomal membrane (Song ZM et al. 2017).
Identifier: R-HSA-1675961
Species: Homo sapiens
Compartment: Golgi membrane, cytosol
At the Golgi membrane, phosphatidylinositol 3-kinase catalytic subunit type 3 (PIK3C3) aka VPS34 is bound to phosphoinositide 3-kinase regulatory subunit 4 (PIK3R4). This PIK3C3:PIK2R4 complex and phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit alpha (PIK3C2A) phosphorylate phosphatidylinositol (PI) to phosphatidylinositol 3-phosphate (PI3P).

The following lists the above proteins with their corresponding literature references: PIK3C3:PIK2R4 (Panaretou et al. 1997, Volinia et al. 1995) and PIK3C2A (Arcaro et al. 2000, Domin et al. 2000).
Identifier: R-HSA-5672012
Species: Homo sapiens
Compartment: endoplasmic reticulum membrane, cytosol
The Beclin-1 complex (ATG14:PIK3C3:PIK3R4:BECN1) is essential for autophagosome formation (Matsunaga et al. 2009, 2010). PIK3C3 (VPS34), the catalytic component of this complex, is a class III phosphatidylinositol 3-kinase that phosphorylates phosphatidylinositol (PI) producing phosphatidylinositol 3-phosphate (PI3P). PIK3C3 is essential for the early stages of autophagy and colocalizes strongly with early autophagosome markers (Axe et al. 2008). The role of PI3P in autophagosome formation is to recruit WIPI2b (Dooley et al. 2014) a member of the WIPI family (Proikas-Cezanne et al. 2004, 2015, Polson et al. 2010).
Identifier: R-HSA-1676024
Species: Homo sapiens
Compartment: late endosome membrane, cytosol
At the late endosome membrane, phosphatidylinositol 3-kinase catalytic subunit type 3 (PIK3C3) aka VPS34 binds to phosphoinositide 3-kinase regulatory subunit 4 (PIK3R4). The PIK3C3:PIK3R4 complex and phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit alpha (PIK3C2A) phosphorylate phosphatidylinositol (PI) to phosphatidylinositol 3-phosphate (PI3P).

The following lists the above proteins with their corresponding literature references: PIK3C3:PIK3R4 (Panaretou et al. 1997, Volinia et al. 1995, Cao et al. 2007) and PIK3C2A (Arcaro et al. 2000, Domin et al. 2000).
Identifier: R-HSA-1675939
Species: Homo sapiens
Compartment: early endosome membrane, cytosol
At the early endosome membrane, phosphatidylinositol 3-kinase catalytic subunit type 3 (PIK3C3) aka VPS34 binds to phosphoinositide 3-kinase regulatory subunit 4 (PIK3R4). The PIK3C3:PIK3R4 complex and phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit alpha (PIK3C2A) phosphorylate phosphatidylinositol (PI) to phosphatidylinositol 3-phosphate (PI3P).

The following lists the above proteins with their corresponding literature references: PIK3C3:PIK3R4 complex (Panaretou et al. 1997, Volinia et al. 1995, Cao et al. 2007) and PIK3C2A (Arcaro et al. 2000, Domin et al. 2000).
Identifier: R-HSA-5678313
Species: Homo sapiens
Compartment: cytosol
AMBRA1 (activating molecule in Beclin 1-related autophagy 1) is a mammalian scaffold protein that interacts with BECN1 (Beclin-1) in the Beclin-1 complex, which consists of BECN1, PIK3C3 (VPS34), PIK3R4 (VPS15) and ATG14. AMBRA1 promotes the interaction of BECN1 with PIK3C3 (Fimia et al. 2007). AMBRA1 can simultaneously bind dynein and the Beclin-1 complex. This anchors Beclin-1 complexes to the cytoplasmic microtubule network (Di Bartolomeo et al. 2010, Fimia et al. 2011). Downregulation of AMBRA1 increased staurosporine- or etoposide-induced apoptosis (Gu et al. 2014).
Identifier: R-HSA-5679205
Species: Homo sapiens
Compartment: cytosol, endoplasmic reticulum membrane
Following amino-acid starvation or mTOR inhibition, activated ULK1 phosphorylates BECN1 (Beclin-1) on Ser-15, thereby enhancing the activity of PIK3C3 (Vps34) in the Beclin-1 complex. This phosphorylation is required for full autophagic induction in mammals (Russell et al. 2013).
Identifier: R-HSA-6781779
Species: Homo sapiens
Compartment: cytosol
USP13 preferentially cleaves Lys-63-linked polyubiquitin chains (Zhang et al. 2011). It mediates deubiquitination of BECN1, a key regulator of autophagy, which stabilizes PIK3C3/VPS34-containing complexes. USP13 can deubiquitinate USP10, an essential regulator of TP53 stability (Liu et al. 2011).
Identifier: R-HSA-5679266
Species: Homo sapiens
Compartment: cytosol, endoplasmic reticulum membrane
The Beclin-1 complex (ATG14:PIK3C3:PIK3R4:BECN1) associates with the endoplasmic reticulum (ER). The ATG14 component of the complex contains an ER-binding motif in its N-terminal domain, which appears to be essential for its function in autophagy and for the recruitment of the other Beclin-1 complex subunits to the site of phagophore formation (Matsunaga et al. 2010). N-terminal myristoylation of the PIK3R4 (p150) component may also anchor the Beclin-1 complex to the membrane (Panaretou et al. 1997, Wirth et al. 2013).
Cite Us!